Lecture 3 Flashcards
Log dose of Quantal Data
Normal distribution
The lower the LD50,_______________
The more toxic
LD50
Lethal dose for 50% of the population
Show normal distribution when expressed as the frequency of response.
Quantal dose-responses
Bliss
- Relatively high proportion of resistant
insects, thus curve skewed to right. - Expressed x-axis as log dose to give
normal curve (frequency
distribution curve).
LC50
Median Lethal Concentration (Airborne concentration)
TD50
Medial Toxic Dose (Toxic to the liver)
ED50
Median Effective Dose (Kills pain for 50% of the population)
NOAEL
(No Observed Adverse Effect
Level):
– The highest dose of a chemical that causes no
observable toxic effect in test subjects.
LOAEL
(Lowest Observed Adverse
Effect Level):
– The lowest dose of a chemical that causes an
observable toxic effect in test subjects.
FEL
(Frank Effect Level):
– Doses above the LOAEL that cause clearly
toxic effects in test subjects.
Potency
– Reflected by the position of the dose-response curve along the x-axis.
– The farther to the left the more potent the compound
Efficacy
– Reflected by the peak of the dose-response curve.
– A higher peak indicates greater maximum effect or efficacy.
How to find Therapeutic Index (TI)
LD50/ED50
How to find Margin of Safety (MoS)
LD01/ED99
