Lecture 23: Lactation Flashcards
Which part of the mammary gland consist of the “cluster of milk containing the alveoli?”
Secretory Lobule
Which synthesize and secrete milk
Alveolar Cell
Which contract to decrease the volume of alveoli
Myoepithelial cell
What are the 5 steps of milk synthesis and secretion
- Secretory Pathway
- Transcellular endocytosis/exocytosis
- Lipid Pathway
- Transcellular salt and water transport through channels and transport
- Paracellluar pathway for ions and water
What 3 substances are in the secretory pathway?
- Casein
- Salts
- Sugar
What 3 substances are in the Transcellular Endocytosis/Exocytosis?
- Immunoglobulins
- Hormones
- Growth Factors
What does Mammogenic Hormones do?
Promote Cell Proliferation
What 4 substances are affected by Lobulo-Alveolar Growth?
- Estorgen
- Growth Hormones
- Cortisol
- Prolactin
What 3 substances are affected by Ductal Growth?
- Estrogen
- Growth Hormone
- Cortisol
What do Lactogenic Hormones do?
Promote initiation of milk production by alveolar cells
What 5 hormones affected by Lactogenic?
- Prolactin
- Human Chorionic Somatomammotropin
- Cortisol
- Insulin (affect premies)
- Thyroid Hormones
What other hormones are in the same family of Somatomammotropin
GH and Prolactin
What two hormones inhibit milk production?
What do they do?
Estrogen: Removal of inhibition with parturition permits lactation
Progesterone: Combination OCPs may interfere with lactation
What does Galactokinetic Hormones do? name a hormone affected by it?
Promote contraction of myoepithelial cells and milk ejection
- Oxytocin
What does Galactopoietic Hormones do? what 2 hormones affected by it
Maintain milk production after it has been established
- Prolactin and GH
What is rBST and rBGH?
what do they do?
- recombinant Bovine Somatotropin
- recombinant Bovine Growth Hormones
- increases milk yield in lactating cows
Which hormone removes inhibition?
Dopamine
Which hormone affects the Epithelial Cells?
Prolactin