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PSIO 469 Exam 04 > Lecture 22: HPV Vaccine > Flashcards

Lecture 22: HPV Vaccine Flashcards

1
Q

Cervical Cancer is __ most frequent diagnosed cancer in women worldwide.
Cervical Cancer is most commonly diagnosed cancer among women in ____ &____ _____
___ out of 10 cervical cancer deaths occurs in less _____countries

A

4th
Eastern & Middle Africa
9; developed

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2
Q

What is “Malignant Neoplasm?”

A

a tumor that tends to grow, invade, and metastasize

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3
Q

What is “HPV?”

A
  • Human Papillomavirus
  • Double stranded circular DNA episome
  • Surrounded by 72 pentametic (5-sided) capsules
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4
Q

In HPV, these genes encode for capsid proteins?

A

L1 and L2

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5
Q

individual capsids will assemble into ___-____ ____ (___) when expressed in microbial organisms

A

Virus-like particles (VLPs)

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6
Q

VLPs lack:

A

Viral DNA

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7
Q

What is an “Oncogene?”

A

Gene that causes transformation of normal cells into cancerous tumor cells, especially viral gene that transforms host cell into tumor cells

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8
Q

HPV 16 accounts for nearly 50-60% of all:

A

Cervical Cancer

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9
Q

HPV 18 accounts for 10-20% of all:

A

Cervical Cancer

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10
Q

HPV 6 and 11 are associated with 90% of:

A

genital warts

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11
Q

The ____ separates the uterus from the vagina.

The cervix has flat ______ cells in region near vagina

A

cervix

squamous

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12
Q

What are “Squamous cells?”

A

Plate-like (thin and flat)

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13
Q

What is “Dysplasia?”

A

Alteration in size, shape and organization of adult cells

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14
Q

What is “Carcinoma?”

A

malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues

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15
Q

HPV doesn’t always lead to cervical cancer.

T/F

A

True

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16
Q

__% are transient, asymptomatic, and resolve without treatment and HPV is no longer detectable in _____

A

80%

cervix

17
Q

In women with intact immune system, HPV infection generally resolves without intervention within:

A

18-24 months

18
Q

What is “LSIL?”

A

Low grade Squamous Intraepithelial Lesion

aka Mild Dysplasia

19
Q

What is “HSIL?”

A

High grade Squamous Intraepithelial Lesion

aka moderate to severe dysplasia

20
Q

__% of women <25 are positive for HPV.
Up to __% of sexually active college-age students are HPV infected.
__% of women >45 are positive for HPV

A

30%
70%
3%

21
Q

What is a PAP Test

A

screening test to detect premalignant and malignant cells in the cervix

22
Q

How does a PAP test work?

A
  • Cells are collected from outer opening of cervix

- cell are placed on glass slide and checked for abnormalities under microscope

23
Q

How does a flashlight- vinegar test work?

A

1) health worker looks at cervix with flashlight and swabs with vinegar
2) spots that run white may be precancerous legions

24
Q

Do young women who have LSIL require treatment?

A

no, because it usually goes away by itself

25
Q

If LSIL persists or progresses to HSIL then how is it treated?

A
  • Loop Electrosurgical Excision Procedure (LEEP)

- Cryotherapy

26
Q

What is LEEP?

A

A procedure where a thin wire loop carrying electric current is used to remove abnormal areas of cervix

27
Q

What is Cryotherapy?

A

A procedure where abnormal tissue is frozen and later shed by the body

28
Q

How does the HPV Vaccine work?

HPV Capsid proteins can assemble into ___-___ ______ (___)

A

Virus-like particles (VLPs)

29
Q

How does the HPV Vaccine work?

Specific HPV VLPs elicit robust _____ response

A

Antibody

30
Q

Gardasil includes VLPs from HPV:

how many valences is it?

A

16, 18, 31, 33, 45, 52, 6 and 11

9-valent

31
Q

In June 2006, FDA approved Gardasil for females ages:

A

9-26

32
Q

___% of US youths have intercourse by age 13.

___% have intercourse by Grade 12

A
  1. 4%

46. 7%

33
Q

Is it recommended after onset of sexual activity, even if there has been abnormal Pap or HPV DNA test or genital warts?

A

Yes, because the vaccine can protect against HPV types not already acquired

34
Q

What is another reasons it is recommended for?

When is it not recommended?

A
  • for immuno-suppressed women due to high risk for persistent HPV infection
  • For newborn immunization because duration of protection is unclear
35
Q

In October 2009, FDA approved Gardasil for males ages:

A

9-26

36
Q

Which HPV in males gives them genital warts?

A

HPV 6 and 11

37
Q

Boys are prone to HPV-related cancers as girls.

T/F

A

False, they are not prone

38
Q

Boys are involved with the transmission of HPV.

T/F

A

True

PSIO 469 Exam 04 (5 decks)

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