Lecture 22: HPV Vaccine Flashcards
Cervical Cancer is __ most frequent diagnosed cancer in women worldwide.
Cervical Cancer is most commonly diagnosed cancer among women in ____ &____ _____
___ out of 10 cervical cancer deaths occurs in less _____countries
4th
Eastern & Middle Africa
9; developed
What is “Malignant Neoplasm?”
a tumor that tends to grow, invade, and metastasize
What is “HPV?”
- Human Papillomavirus
- Double stranded circular DNA episome
- Surrounded by 72 pentametic (5-sided) capsules
In HPV, these genes encode for capsid proteins?
L1 and L2
individual capsids will assemble into ___-____ ____ (___) when expressed in microbial organisms
Virus-like particles (VLPs)
VLPs lack:
Viral DNA
What is an “Oncogene?”
Gene that causes transformation of normal cells into cancerous tumor cells, especially viral gene that transforms host cell into tumor cells
HPV 16 accounts for nearly 50-60% of all:
Cervical Cancer
HPV 18 accounts for 10-20% of all:
Cervical Cancer
HPV 6 and 11 are associated with 90% of:
genital warts
The ____ separates the uterus from the vagina.
The cervix has flat ______ cells in region near vagina
cervix
squamous
What are “Squamous cells?”
Plate-like (thin and flat)
What is “Dysplasia?”
Alteration in size, shape and organization of adult cells
What is “Carcinoma?”
malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues
HPV doesn’t always lead to cervical cancer.
T/F
True
__% are transient, asymptomatic, and resolve without treatment and HPV is no longer detectable in _____
80%
cervix
In women with intact immune system, HPV infection generally resolves without intervention within:
18-24 months
What is “LSIL?”
Low grade Squamous Intraepithelial Lesion
aka Mild Dysplasia
What is “HSIL?”
High grade Squamous Intraepithelial Lesion
aka moderate to severe dysplasia
__% of women <25 are positive for HPV.
Up to __% of sexually active college-age students are HPV infected.
__% of women >45 are positive for HPV
30%
70%
3%
What is a PAP Test
screening test to detect premalignant and malignant cells in the cervix
How does a PAP test work?
- Cells are collected from outer opening of cervix
- cell are placed on glass slide and checked for abnormalities under microscope
How does a flashlight- vinegar test work?
1) health worker looks at cervix with flashlight and swabs with vinegar
2) spots that run white may be precancerous legions
Do young women who have LSIL require treatment?
no, because it usually goes away by itself
