Lecture 22- Human nutrition Flashcards

1
Q

What are functional foods?

A
  • “Foods that provide benefits beyond basic nutrition”
  • Food innovation
  • Connecting food with population health messages
  • “healthy foods”
  • Estimated worth of US $30-50 billion
  • AUS $1 billion in 2003, growing 8-14% per annum
  • Opportunity to grow the market in Australia
  • Export opportunities
  • National Centre for excellence in Functional Foods
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2
Q

What are the opportunities for functional foods in terms of business?

A
  • Opportunities for:
  • Primary industry
  • manufacturing/processing
  • Retailing
  • Minimally transformed foods
  • Contain known bioactives (fruits & veg)
  • Substantially & elaborately transformed
  • Food & beverage ingredients
  • Added bioactives
  • Success depends on consumer responsiveness • Time poor consumers • Need for convenience • People are more interested / aware of what is in their food (publicity)
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3
Q

What are some of the functional foods?

A
  • omega 3
  • probiotics
  • high fibre
  • energy drinks
  • fortified alcohol
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4
Q

What is the case with omega 3?

A
  • Added Omega-3 DHA
  • E.g. Dairy farmers kids milk has 75% RDI of Omega-3 in 250mL
  • Omega-3 enriched eggs • Fed flaxseeds
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5
Q

What about heart health functional foods?

A

• Contains plant sterols that lower LDl cholesterol, margerine and milk

  • recent evidence suggests that similar effects can be gained from consuming lower doses of these sterols
  • consumption of plant foods
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6
Q

What about probiotics?

A
  • advertised as the magic bullet
  • contains microorganisms (bacteria etc.), GI tract targeted
  • there are benefits when taking biotic
  • reduce the severity of the diarrhea
  • prevent the onset of diarrhea
  • IBS= mixed evidence
  • we discussed the microbiome, are they not all different?
  • a better treatment, faecal transplant =cured 94% of infections, diarrhea,(antibiotics cure 27%)
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7
Q

What about high fibre?

A
  • important for GI tract
  • can reduce incidence of some cancers and heart disease
  • too much fibre?
  • more than 50-60g per day can reduce mineral and vitamin absorption and causes GI discomfort
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8
Q

What about energy drinks?

A
  • Consumption is increasing
  • Particularly in adolescents
  • Higher in males
  • Caffeine does improve attention
  • Temporary
  • Reduces memory
  • Energy drinks:
  • Decrease reaction time
  • Increase alertness
  • Improve memory & concentration
  • Increase exercise endurance

-limited evidence that they improve energy, some ingredients have not been established as safe

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9
Q

What is the case with fortified alcohol?

A
  • Added alcohol in wine
  • Alcohol + energy drinks
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10
Q

Have many functional foods exaggerated the health claims?

A
  • In Sept 2009 Dannon settled a case for US $35 million
  • Exaggerated health benefits in yoghurt products (Activa)
  • They had to change the labelling
  • “clinically proven” etc.
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11
Q

When does food preference in humans develop?

A
  • Develop in utero?
  • What is consumed in pregnancy may shape food preferences for baby
  • Sensory stimuli can be perceived during the latter stages in utero
  • Foods can ‘flavour’ the amniotic fluid & milk
  • E.g. vanilla, carrot, garlic, mint, anise etc.
  • Food experienced in utero are accepted better once born
  • Nature Vs nurture
  • Siblings raised the same way can have varied preferences
  • Genetic influences on taste? (BUT not specific to foods)
  • Role for both preference and aversion
  • Religion, demographics, race, age, socioeconomics etc.
  • Cannot discount the role of social activities and influences
  • Classical conditioning
  • Pavlov’s dogs
  • Bad flavours or ill feelings lead to food aversions
  • Reflex responses to tastes are present in the neonate
  • Prefer sweet
  • Reject sour and bitter foods
  • Preference for salt develops at about 4 months old
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12
Q

What do twin studies tell us about food preference?

A
  • Studies of twins show:
  • A substantial genetic effect on protein tastes (umami)
  • Moderate genetic effect on veggies and fruits
  • Small genetic effect on sweet tastes
  • Preferences for dairy and starch are highly environment driven
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13
Q

What is the problem of obesity like?

A
  • Food selection has a strong adaptive value
  • So does the storage of energy
  • Advantage when resources are scarce
  • In 2005, WHO reported that >400 million adults are obese
  • Complex interactions between genetic, nutritional, metabolic, hormonal, medical, behavioural and environmental factors
  • Role of food preferences?
  • Particularly in children
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14
Q

What are homeostatic signals?

A
  • maintenance of physiological equlibrium
  • Insulin
  • Glucagon
  • Catecholamines (eg. Epinephrine)

-going on all the time, maintain steady glucose level in the body

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15
Q

What is homeorhesis?

A

-the adaption to these process to particular stage in life

  • Pregnancy
  • Lactation
  • Growth
  • co-ordinated changes in metabolism of body tissues to support a physiological state
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16
Q

How is fat stored, how does this system work?

A
  • if you consume dietary fat, made into glycerols, then nonesterified fatty acid and then into adipocyte for storage= same for glucose
  • this process is positively influenced by insulin and negatively by epinephrin and glucagon (as you would need energy readily)
  • the reverse can also happen when the stored fat is made into available
17
Q

What is the effect of feeding on plasma insulin, glucagon and glucose?

A

-insulin and glucagon keep the glucose low after food intake

18
Q

What happens in the cow after feeding with the insulin?

A
  • really big difference when lactating or dry
  • lactating has lower levels
  • it differs across species
19
Q

What is the hyperinulinemic/euglycemic clamp?

A

• Technique to study insulin metabolism without altering glucose and glucagon

-you give insulin and maintain glucose so can tell that the difference is then due to the efficiency of the animals to maintain homeostasis

  • hyperinsulinemic = high insulin
  • euglycemic = glucose maintenance
  • clamp = keep insulin and glucose constant
  • Infuse insulin to increase plasma insulin while infusing glucose to maintain plasma glucose (glucagon won’t change)
20
Q

Why are these studies done?

A
  • how well are things taken up into fat
  • glucose uptake relative to the insulin
21
Q

What happens when inject glucagon?

A
  • glucagon injection at time zero, then increase in glucose and eventually go back to steady state
  • increase in insulin as well
22
Q

What also happens with glucagon injections?

A

-glucagon then increases the glucose but first have to break down the NEFA (non esterified fatty acids so it can be used by the body)

23
Q

What happens to NEFA when inject epinephrine?

A
  • injection of epinephrine get an increase in plasma NEFA
  • also in glucose
24
Q

What is the homeorhesis?

A
  • Changing metabolism to support a physiological state
  • Can be achieved through altering responses to homeostatic signals
  • changing sensitivity (receptor related= to bind the hormone etc.)
  • changing responsiveness (post-receptor related)
25
Q

What happens in pregnancy and insulin?

A
  • in non pregnant animal, the response rate is different
  • the insulin is different
  • at different stage of pregnancy this also differs
  • how responsive the fat is to provide energy differs, less responsive in early pregnancy then later
26
Q

What happens in pregnancy?

A
  • Decreased sensitivity to insulin with respect to glucose utilisation (need more)
  • Marginal changes in responsiveness to insulin of endogenous glucose production
  • Decreased responsiveness to insulin with respect to NEFA metabolism
  • Increased responsiveness to catecholamines

-more stress responsive when pregnant

27
Q

What is the glucose uptake in pregnant and dry animals in their hind limbs?

A
  • glucose uptake in the hindlimb
  • in dry animal more readily uptaken
  • when pregnant won’t take it up as quickly since want circling glucose for the fetus
28
Q

How do animals respond to an epinephrine challenge?

A
  • dry animal doesn’t really respond to the epinephrine
  • the pregnant does
  • lactating even more!
29
Q

What about lactation in general?

A
  • Decreased sensitivity and responsiveness to insulin with respect to glucose utilisation
  • Decreased responsiveness to insulin of endogenous glucose production
  • Decreased responsiveness to insulin with respect to NEFA metabolism?
  • Increased responsiveness to catecholamines
30
Q

What are the homeorhetic signals?

A

• Bauman and Currie (1980)

  • somatotropin
  • placental lactogen
  • prolactin

• Bines and Hart (1982)

• somatotropin

31
Q

What effect does somatotropin have?

A
  • somatotropin (growth hormone)
  • high yielding animal has more, and is more responsive
32
Q

What about responsiveness to insulin?

A

-high yielding animal is also more responsive

33
Q

What is true of milking cows?

A
  • Negative energy balance is NOT more severe in TMR fed genetically superior cows (may not be the case for pasture cows)
  • the cow produces more and doesn’t expend more energy
34
Q

What happens if inject bST (bovine somatotropin)?

A
  • increase in productive input
  • bigger decrease in energy balance so will need more energy input to not waste
  • see more NEFA in plasma as need more energy
  • become more sensitive to epinephrine (so more responsive to stress)
  • they don’t respond to insulin as much
35
Q

What is the case with somatotropin?

A
  • Increases responsiveness to catecholamines
  • Reduces responsiveness with respect to glucose insulin stimulation of glucose utilisation by peripheral tissues
  • Reduces effect of insulin in inhibiting hepatic glucose production
  • Metabolic effects similar in lactating and growing animals