Lecture 22

Question 0

What is involved with immediate hypersensitivity (type 1)

Answer 0

IgE

Question 1

Types of hypersensitivity

Answer 1

1- immediate hypersensitivity
2- antibody mediated
3- immune-complex mediated
4- T-cell mediated

Question 2

What is involved with Antibody mediated hypersensitivity (type 2)

Answer 2

Antibody + complement

Question 3

What is involved with immune complex-mediated (type 3)

Answer 3

Antibody leading to inflammation

Question 4

What is involved with T cell mediated hypersensitivity (type 4)

Answer 4

T-cells

Question 5

Worst consequence of immediate hypersensitivity (type 1)

Answer 5

Anaphylaxis

Question 6

Good example of antibody p-mediated hypersensitivity (type 2)

Answer 6

Blood incompatibility

Question 7

Universal donor

Answer 7

O-

Question 8

Universal recipient

Answer 8

AB+

Question 9

Examples of immune complex-mediated (type 3) hypersensitivity

Answer 9

Systemic lupus erythematosus, rheumatoid arthritis, serum sickness, rheumatic fever

Question 10

4 steps to type 3 hypersensitivity reaction

Answer 10

1. Immune complexes
2. Deposition
3. Complement and histamine
4. Inflammation

Question 11

When do symptoms of type 4 hypersensitivity arise

Answer 11

One to several days following the second contact with an antigen

Question 12

When does Tuberculin reaction occur? What is it a example of?

Answer 12

Appears 24-48 hours later

Example of a T-cell mediated hypersensitivity reaction (type 4)

Question 13

What do successful transplants require

Answer 13

MHC match

Question 14

Systemic lupus erythematous

Answer 14

Systemic
Mainly type 3 hypersensitivity
Inflammation of many organs, antibodies against cell membranes, DNA, etc

Question 15

Rheumatoid arthritis

Answer 15

Systemic
Anti-antibody antibodies
Vasculitis: inflammation of blood and lymph vessels + flexible (synovial) joints

Question 16

Myasthenia gravis

Answer 16

Muscle specific
Type 3
Antibodies against acetylcholine receptors at nerve junction

Question 17

Type 1 diabetes

Answer 17

Pancreas specific

T cells attack insulin producing cells

Question 18

Multiple sclerosis

Answer 18

Brain and spinal cord

T cells and antibodies destroy myelin sheath insulating neurons

Question 19

What does HIV specifically infect and kill

Answer 19

CD4 T cells, the helper cells in antibody production

Question 20

Autoimmunity most frequently is a failure of the immune system to….

Answer 20

Control self reactive cells

Question 21

Type of antibody found on mast cells

Answer 21

IgE

Question 22

The universal blood recipient is AB+ because all AB+ blood lacks….

Answer 22

AB antibodies

Question 23

What is RhoGAM composed of

Answer 23

Anti-Rh antibody

Question 24

When is the immune system considered severely weakened

Answer 24

When there are less than 200 T-cells/cubic mm