Lecture 22 Flashcards
What is involved with immediate hypersensitivity (type 1)
IgE
Types of hypersensitivity
1- immediate hypersensitivity
2- antibody mediated
3- immune-complex mediated
4- T-cell mediated
What is involved with Antibody mediated hypersensitivity (type 2)
Antibody + complement
What is involved with immune complex-mediated (type 3)
Antibody leading to inflammation
What is involved with T cell mediated hypersensitivity (type 4)
T-cells
Worst consequence of immediate hypersensitivity (type 1)
Anaphylaxis
Good example of antibody p-mediated hypersensitivity (type 2)
Blood incompatibility
Universal donor
O-
Universal recipient
AB+
Examples of immune complex-mediated (type 3) hypersensitivity
Systemic lupus erythematosus, rheumatoid arthritis, serum sickness, rheumatic fever
4 steps to type 3 hypersensitivity reaction
- Immune complexes
- Deposition
- Complement and histamine
- Inflammation
When do symptoms of type 4 hypersensitivity arise
One to several days following the second contact with an antigen
When does Tuberculin reaction occur? What is it a example of?
Appears 24-48 hours later
Example of a T-cell mediated hypersensitivity reaction (type 4)
What do successful transplants require
MHC match
Systemic lupus erythematous
Systemic
Mainly type 3 hypersensitivity
Inflammation of many organs, antibodies against cell membranes, DNA, etc
Rheumatoid arthritis
Systemic
Anti-antibody antibodies
Vasculitis: inflammation of blood and lymph vessels + flexible (synovial) joints
Myasthenia gravis
Muscle specific
Type 3
Antibodies against acetylcholine receptors at nerve junction
Type 1 diabetes
Pancreas specific
T cells attack insulin producing cells
Multiple sclerosis
Brain and spinal cord
T cells and antibodies destroy myelin sheath insulating neurons
What does HIV specifically infect and kill
CD4 T cells, the helper cells in antibody production
Autoimmunity most frequently is a failure of the immune system to….
Control self reactive cells
Type of antibody found on mast cells
IgE
The universal blood recipient is AB+ because all AB+ blood lacks….
AB antibodies
What is RhoGAM composed of
Anti-Rh antibody
