Lecture 2020 - Transfusion Medicine

Question 1

Contraindication for platelet transfusion?

Answer 1

Thrombocytopenia due to platelet destruction (in absence of life-threatening bleed)
Examples: ITP, TTP, HIT, MAHA

Question 2

• Cryoprecipitate is ordered in multiples of ____ units?
• Empiric dosing in adults is ___ units?
• 10 units of cryo should increase fibrinogen by ___?

Answer 2

• Cryoprecipitate is ordered in multiples of 5 units
• Empiric dosing in adults is 10 units
• 10 units of cryo should increase fibrinogen by ~100

Question 3

Indications for cryo tranfusion?

Answer 3

• Hypofibrinogenemia with active bleeding, risk of bleeding, or consumptive coagulopathy.
• Functionally abnormal fibrinogen
• Uremic bleeding not responsive to DDAVP
• 2nd line for von-willebrand disease
• 2nd line for hemophilia A

Question 4

Irradiation of blood products is used to prevent which complication?

Answer 4

Transfusion-associated craft-versus host disease