Lecture 2020 - Intro to Stem Cell Transplant

Question 1

What are the 3 main types of matches for bone marrow transplantation?

Answer 1

• HLA matched related donor (sibling
• HLA haploidentical related donor (parent/child)
• HLA matched unrelated donor (higher rates of GVHD due to minor histocompatibility antigens less likely to match transplant recipient if derived from unrelated donor)

Question 2

What common part of many BMT conditioning regimens can be especially useful for tumor cell sanctuary sites?

Answer 2

Total body irradiation