Lecture 20: Human Genetic Variation Flashcards

1
Q

What are examples of biological demographic variables in psychological research?

A

Age, developmental/reproductive stage, health, ability, addiction, sex/gender, sexual orientation, race, ethnicity.

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2
Q

What are examples of non-biological demographic variables?

A

Occupation, work status, leadership, socio-economic status, immigration status, education, family, political views, religion.

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3
Q

What is the traditional reproductive binary in biology?

A

XX = female, XY = male; categorised by chromosomal sex and reproductive roles (egg/sperm parent).

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4
Q

Give two examples of sex chromosome anomalies.

A

Klinefelter syndrome (XXY), Turner syndrome (missing or partial X chromosome), Triple X syndrome (XXX).

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5
Q

What is intersex?

A

A condition involving atypical development of sexual organs, despite typical sex chromosomes (XX or XY).

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6
Q

Why is relying solely on the reproductive binary problematic in research?

A

It overlooks environmental and social factors influencing gender identity and behaviour.

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7
Q

Why is the validity of IQ tests debated?

A

Because IQ scores can improve with training, and they don’t fully capture intelligence as defined by alternative theories.

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8
Q

What is the “g” factor?

A

A statistical general intelligence score derived from correlated task performance.

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9
Q

According to meta-analyses, what explains most variance in school attainment between boys and girls?

A

Environment, parental education, and school type—not biological sex/gender.

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10
Q

What does the Gender Similarity Hypothesis state?

A

That men and women are more alike than different in most psychological traits and abilities.

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11
Q

Why must researchers collect demographic data?

A

To assess selection bias, contextualise findings, and perform subgroup comparisons.

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12
Q

What are ethical responsibilities in research involving human participants?

A

Gaining informed consent for collecting, storing, analysing, and sharing personal data.

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13
Q

Who coined the term “eugenics”?

A

Francis Galton in 1883.

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14
Q

What’s the danger of Social Darwinism?

A

It wrongly applies evolutionary theory to justify social inequality and selective breeding.

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15
Q

What does “scientific racism” refer to?

A

Misuse of genetics to claim superiority of certain races; rooted in eugenics and discredited theories.

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16
Q

What was one consequence of shrinking body sizes during the Industrial Revolution?

A

Sparked research into genetic vs. environmental causes of physical traits like height.

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17
Q

What is anthropometry?

A

Measuring human body, head, and face to study variation (historically misused in race science).

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18
Q

Is height a polygenic trait?

A

Yes, it is influenced by many genes and environmental factors.

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19
Q

What is a SNP?

A

A Single-Nucleotide Polymorphism; a variation at a single position in DNA among individuals.

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20
Q

What causes genetic variation?

A

Mutations, environmental effects on DNA, recombination during egg/sperm production.

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21
Q

What’s the problem with the nature vs. nurture dichotomy?

A

It oversimplifies development; genes and environment interact continuously.

22
Q

What was the goal of the Human Genome Project (HGP)?

A

To completely map all the genes in human beings.

23
Q

When was the HGP active, and when did the full sequence become available?

A

Active from 1984–2004; full sequence became available between 2001–2004.

24
Q

What were the Bermuda Principles established by the HGP?

A

All human genome sequences should be made publicly available within 24 hours, with no delays or exceptions.

25
What major ethical concern arose from the HGP regarding indigenous populations?
They are often the most disadvantaged yet benefit the least from resulting medical and scientific advances.
26
Name two initiatives that work with indigenous communities on genomic projects.
Silent Genomes Project (Canada), Aotearoa Variome Project (New Zealand).
27
What have genetic studies shown about variation within vs. between human populations?
There is more genetic variation within populations than between them.
28
According to the Human Genome Diversity Project, what does this mean for the concept of race?
It discredits a genetic basis for the concept of “race.”
29
What does it mean to say that race is a social construct, not a biological category?
Race is created by social and cultural ideas, not based on biological or genetic evidence.
30
Why is using "race" in genomics research dangerous?
It can mislead, reinforce stereotypes, and support racism (Yudell et al., 2016).
31
When did the term “race” first appear in the English language?
In the late 16th century during European colonisation.
32
How was race used after the abolition of slavery in the 19th century?
Pseudoscientific concepts of race were used to justify social segregation and pathologise inter-ethnic mixing.
33
What term often replaced “race” post-WWII, and what is its origin?
“Ethnicity,” from the Greek ethnos, meaning people
34
What environmental factor is most strongly linked with skin pigmentation?
Ultraviolet (UV) radiation levels.
35
Why did lighter skin evolve in populations living in high latitudes?
Adaptive selection due to lower UV exposure.
36
What is the flaw in earlier studies of skin pigmentation?
Overemphasis on a few genes in European populations; newer research reveals pigmentation is highly polygenic.
37
How has spectrophotometry improved skin colour research?
It accurately measures melanin in less sun-exposed areas (like the underarm).
38
Why is genetic diversity highest in Africa?
Humans have lived longest there, allowing for the most genetic variation to accumulate.
39
What does modern genomics reveal about inheritance of traits like skin colour?
It’s polygenic and complex; many genes with different alleles contribute.
40
What is still lacking in current genetic research?
Representation and understanding of African genetic diversity.
41
What model explains the origin and dispersal of Homo sapiens?
The Out of Africa hypothesis.
42
When did humans first migrate to Australia and the Americas?
Australia: 60–40,000 years ago; Americas: ~20,000 years ago.
43
What does genetic admixture mean?
Mixing of genes from different populations, including other human species like Neanderthals.
44
What is one local genetic adaptation besides skin colour?
Genes that provide resistance to certain diseases or adapt to diet or climate.
45
What does GWAS stand for?
Genome-Wide Association Studies.
46
What do GWAS help identify?
Associations between SNPs and complex, polygenic traits or diseases.
47
What are SNPs?
Single-nucleotide polymorphisms—small, frequent variations in DNA among individuals.
48
What are the benefits of GWAS?
Helps in personalised medicine, identifies disease risk markers, and maps polygenic traits.
49
What are the limitations of GWAS?
Requires massive data sets; risk of false associations; difficulty interpreting non-coding DNA ("dark matter").
50
What are some ethical concerns with GWAS?
Representation, defining “normal,” prediction errors, and privacy/security of genetic data.