Lecture 20: Ethics and Regulation Flashcards

1
Q

What is ethics?

A

Ethics refers to the series of rules provided to an individual by an external source. (ex. government or religion)

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2
Q

What are morals?

A

Morals refer to an individuals OWN principals regarding right and wrong.

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3
Q

What is the importance of blastocysts when discussing ethics and regulation?

A

A blastocyst is a structure formed during the early embryonic development of mammals. It contains an inner cell mass which is what forms the embryo. A blastocyst is a matter of discussion since there are contradictions on whether they are considered “alive” and human the moment they are formed.

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4
Q

What is in vitro fertilization?

A

In vitro fertilization is the procedure of helping conceive a child by collecting eggs and sperm and artificially fertilizing in a dish then placing them into a uterus.

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5
Q

What is the issue with IVF?

A

-IVF is a really expensive process.
-not covered by insurance

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6
Q

What happens to IVF blastocysts ?

A

After the mother has become pregnant, they have a choice to continue paying for their storage but usually they are discarded since insurance does not help pay.

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7
Q

What are the views of IVF patients?

A

most of them have donated their blastocysts to research

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8
Q

What did former President Bush do?

A

He banned federal funding of any human stem cell lines made after the date of his law.

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9
Q

2004 California State Proposition 71

A

a successful campaign that was passed for stem cell research
-passed with 59% of vote
-established CIRM
-provided $3 billion of stem cell research in CA
-lead to other states having funding in later years (NJ, NY, CO)

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10
Q

How did the $3 billion investment in CIRM affect CA?

A

there was a more than threefold return on investment to California.
-cost $3 billion but CA had an economic impact of $10.7 billion

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11
Q

Who ended the stem cell research ban?

A

In 2009, former President Obama ended the SC research ban.
-now researchers could apply for federal funding

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12
Q

What are the state and country regulations on stem cell research?

A

Well, it varies from state to state in the US.
- it also varies country to country in the world since each country has different laws on SCR

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13
Q

Who will pay for stem cell treatments?

A

This is still unknown!
Will it be insurance, government or patients paying for it?
-leads to only rich people being able to afford these kinds of treatments.

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14
Q

Is the catholic church okay with iPSC research?

A

Actually, the Catholic Church is okay with iPSC research. Yamanaka was named member of the pontifical academy of science by Pope Francis.

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15
Q

Do we still need to use embryonic stem cells?

A

There are some genetic differences between iPSCs and ESCs
- Female human iPS cells retain an inactive X- chromosome.
-genetic disease is better treated with iPSc

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16
Q

Can you clone a human?

A

Well, there was a sheep named Dolly that was cloned.

17
Q

What are the regulations on cloning?

A

The federal government has not yet agreed on how to regulate human cloning.

18
Q

What is SCNT (somatic cell nuclear transfer)?

A

the method used to make Dolly the sheep. It involves the transfer of the nucleus of a somatic cell into the cytoplasm of an egg whose own chromosomes have been removed.

19
Q

Sperm and eggs can both be made from ___

A

mouse ESCs and iPSCs

20
Q

Eggs can now also be made from ___

A

human ESCs and iPSCs
-they are lab grown human eggs!

21
Q

What can Blastocysts like structures be made from?

A

iPSCs

22
Q

How are cerebral organoids changing the field?

A

-they are only 4mm wide but can show cortical layers and hippocampus.
-have showed electrical patterns that resemble those of premature babies.

23
Q

What is wrong with cerebral organoids?

A

-they develop unorganized when compared to a real human brain
-they take time to grow

24
Q

List the 3 ways to clone a person.

A
  1. somatic cell nuclear transfer (Dolly)
  2. make sperm and eggs
  3. make blastocysts from iPSCs