Lecture 2 - VLDL and LDL

Question 1

What are VLDL?

Answer 1

Very low density lipoprotein

More cholesterol than chylomicrons CE:FC = 1:1

FC = free cholesterol

Uses Apo B100, E and C

Secreted from liver and processed in plasma to LDL

Question 2

How is VLDL processed in the plasma?

Answer 2

VLDL gain most of their apoC,E and CE from HDL in the plasma.

apoC is cleaved by Lipoprotein lipase and becomes an intermediate density lipoprotein (IDL)

Question 3

How is intermidiate density lipoprotein processed to LDL?

Answer 3

Hepatic lipases remove more TAG, some ppl and apoE

Both LDL and VLDL remnants are removed by LDL receptors. This relies on B100, VLDL at liver, LDL at peripheral tissue

Question 4

How much cholesterol bodies do LDL lipoproteins transport?

Answer 4

60% bodies of cholesterol
-75% as CE and 25% as FC

90% of LDL apoprotein is Apo-B100