Lecture 2: Proprioception and Tactile Pathways Flashcards
What are the 4 pathways which transmit different types of somatic sensations (i.e., touch, vibration, proprioception, etc..)?
- Posterior column-medial lemniscal
- Trigeminolthalamic pathways
- Spinocerebellar pathways
- Anterolateral system
What is the primary pathway that transmits discriminative touch, flutter-vibration, and proprioceptive information?
Posterior column-medial lemniscal pathway
Size, shape, and texture discrimination, recognition of 3-D shape (stereognosis), motion detection, concious awarness of body positon (proprioception) and limb movement (kinesthesia) involve which system?
Posterior column-medial lemniscal system (PCMLS)
What are the characteristic features in terms of afferent fiber conduction, synaptic relays, and somatotopic organization of the PCMLS?
- Afferent fibers with fast conduction velocities and limited number of synaptic relays
- Precise somatotopic organization
- Basis for the accurate localization of touch on different parts of the body, with high fidelity and a high degree of spatial/temporal resolution
What is frequency vs. population coding?
Frequency = cell’s firing rate signals stimulus intensity or temporal aspects of the tactile stimulus
Population = distribution in time/space of the number of activated cells signals location of the stimulus as well as its motion/direction
The high degree of resolution of the PCMLS results from what; sharpening discrimination between separate points on the skin is critical for?
- Inhibitory mechanisms such as: feed-forward, feedback, and lateral (surround) inhibition
- Critical for two-point discrimination
Why does two-point discrimination vary widely over different parts of the body?
Related to the density of peripheral nerve endings
If the mechanical pressure applied to peripheral mechanoreceptors is great enough what will occur?
- Mechanical pressure is transduced into an electrical signal by the primary afferent neuron
- If this depolarizes the neuron to threshold, an action potential is produced and relayed to the CNS via PCMLS
- Somatic sensations of touch are evoked

What is the tactile receptor density of the digits and perioral region vs. other regions, such as the back?
- Digits and perioral regions have increased density of tactile receptors
- Other regions, like the back have decreased density
*Accuracy with which a tactile stimulus is localized depends on receptor density and receptive field size

What is a receptive field and where are there small and large receptive fields; how does this affect sensory discrimination?
- Area of skin innervated by branches of a somatic afferent fiber
- Small receptive fields are found in areas such as fingertips, where receptor density is high = increased discrimination
- Large receptive fields are present in areas with low receptor density (i.e., the back) = decreased discrimination

What is the relationship like between the size of the receptive field and representation of that body part in the somatosensory cortex?
- Inverse relationship
- Small receptive fields = larger representation
- Densely innervated body parts are represented by greater number of neurons —> Take up a disproportionally large part of the somatosensory cortex
- Fingertips and lips provide CNS w/ most specific and detailed info about tactile stimulus
Primary afferent fibers consist of what 3 parts and what are their locations?
- A peripheral process extending from the DRG (mechanoreceptor or free nerve ending)
- A central process extending from DRG into CNS
- A pseudounipolar cell body in the DRG

Large-diameter primary sensory fibers relay what type of information; these fibers enter the spinal cord via?
- Discriminative touch, flutter-vibration and proprioception
- Enter the spinal cord via the medial division of the posterior root and then branch
After large-diameter primary sensory fibers enter the spinal cord via the medial division of the posterior root and branch what occurs to these branches; especially the largest set of branches?
- One set of branches terminates on second-order neurons in the spinal cord gray matter at, above, and below the level of entry
- Largest set of branches ascends cranially and contributes to the formation of the fasciculus gracilus and fasciculus cuneatus —> collectively termed the posterior columns
How are sacral level fibers up to T6 positioned topographically within the posterior columns; what contribution of posterior column do these fibers ultimately form?
- Sacral level fibers are positioned medially
- Fibers from more rostral levels (up to T6) are added laterally
- Forms the fasciculus gracilus

How are fibers above T6 and cervical fibers organized topographically in the posterior columns and what do they ultimately form?
- Thoracic level above T6 will be more medial
- Low cervical will be lateral to this and upper cervicals will be most lateral
- Form the laterally placed, fasciculus cuneatus

How do SC lesions affect discriminative, positional, and vibratory tactile sensations?
- Ipsilateral reduction or loss
- At and below the segmental level of injury
SC lesions resulting in ipsilateral reduction or loss of discriminative, postional, and vibratory tactile senations at or below the segmental level of injury will present how?
- Sensory ataxia, loss of muscle stretch (tendon) reflexes and proprioceptive losses from the extremities due to lack of sensory input
- Patient may also have a wide-based stance and may place the feet to the floor with force, in an effort to create the missing proprioceptive input
What are the 2 posterior column nuclei, where are they located, what type of neurons do they contain, what type of input do they receive?
- Nucleus gracilus and nucleus cuneatus are in posterior medulla
- Contain second-order neurons of the PCMLS
- Receive input from first-order neurons (primary afferents) from the ipsilateral DRG

How do core “clusters” and outer “shells” of posterior column nuclei (nucleus gracilus and nucleus cuneatus) contribute to the segregation of tactile inputs?
- Core “clusters” receive inputs from rapidly and slowly adapting afferents
- Outer “shells” receive inputs from muscle spindles, joints, and Pacinian corpuscles

Explain the route of the axons from the second-order neurons of the posterior column as they ascend, where do they decussate, what do they ascend as and what happens to the fiber?
- The axons of second-order sensory neurons of the posterior column are known as internal arcuate fibers, which loop anteromedially in medulla
- Cross the midline as the sensory decussation, causing the axons of the nuclei to be sent to the contralateral thalamus
- Ascend as the medial lemniscus (ML) on the opposite side
- As ML extends rostrally, it rotates laterally in pons. UE fibers are now medial and LE fibers are now lateral

Somatotopic organization of the body is maintained as the medial lemniscus terminates where?
Ventral posterolateral nucleus (VPL) of the thalamus

PC lesions at brainstem levels lead to deficits in; on what side?
- Deficits in discriminative touch, vibratory, and positional sensibilities
- Over the CONTRALATERAL side of the body from the lesion

What are the 2 ventral posterior nuclei, what separates them, and which is specific for the information from the head and the body?
- Ventral posterolateral nucleus (VPL) receives body proprioceptive info
- Ventral posteromedial nucleus (VPM) receives head prorioceptive information
- Separated by fibers of the arcuate lamina

The VPL and VPM are supplied by which arterial branches and what does compromise of this artery lead to?
- Thalamogeniculate branches of Posterior Cerebral artery
- Compromise can result in loss of all tactile sensation over the contralateral body and head

How do fibers from the contralateral nucleus cuneatus terminate in the VPL versus fibers of the nucleus gracilus?
- Fibers from the contralateral nucleus cuneatus terminate medial to those of nucleus gracilis
- Remember that the nucleus cuneatus started lateral and the gracilis was medial, but as ML extends rostrally, it rotates laterally in the pons and the fibers switch postions
How do rapid/slowly adapting inputs target the VPL vs. Pacinian and joint/muscle inputs?
- Rapidly and slow adapting inputs target the VPL core
- Pacinian and joint/muscle inputs target VPL shell

The VPL for the trunk and extremities contains 2 populations of identified neurons, what are their functions?
- Third-order neurons: large-diameter axons that traverse posterior limb of the internal capsule and terminate in the primary (S1) and secondary (SII) somatosensory cortices
- Local circuit interneurons (inhibitory): receive excitatory corticothalamic inputs and influence the firing rates of third-order neurons
Axons from third-order neurons (thalamus) terminate in primary somatosensory (S1) cortex, which comprises which gyri and sulci?
- Postcentral gyrus and posterior paracentral gyrus
- Bordered by central sulcus (anteriorly) and postcentral sulcus (posteriorly)

Which 2 arteries provide blood supply to the SI cortical areas; which artery if compromised produces loss over upper body/face and which for lower limb?
- The ACA and MCA
- MCA lesions = tactile loss over contralateral upper body and face
- ACA lesions = tactile loss over contralateral lower limb

What are the functional subdivisions of the primary somatosensory cortex (S1) from anterior to posterior?
- Broadmann areas: 3a, 3b, 1 and 2
- Area 3a: located in depths of the central sulcus, abuts area 4 (primary motor cortex)
- Areas 3b and 1: extend up the bank of the sulcus onto the shoulder of postcentral gyrus
- Area 2: lies on the gyral surface and abuts area 5 (somatosensory association cortex)

Lesions in subdivision area 1, area 2, and area 3b of the somatosensory cortex would produce what kind of deficits; which is the most profound and what does this suggest?
- Lesions in area 1 produce a deficit in texture discrimination
- Lesions in area 2 result in a loss of size and shape discrimination (astereognosis)
- Lesions in area 3b have a more profound effect —> deficits in both texture and size/shape discrimination
- Suggests that there is hieracrchial processing of tactile information in SI cortex and that area 3b performs initial processing and distributes information to areas 1 and 2
Typically, SI lesions include larger areas, encompassing mutliple subdivision and result in what kind of deficits?
Loss of proprioception, position sense, vibratory sense, and pain/thermal sensations on the contralateral side of the body
How is it possible to have cross sensory syndrome/findings with brainstem lesions?
- Sensory deficits of trunk/extremities contralateral to lesion, but sensory deficits of face/CN ipsilateral to lesion
- The right face and left arm/leg lack proprioceptive info
- All dependent on where the fibers cross and damage occuring at one level will likely damage multiple tracts.

Where is the Secondary Somatosensory (SII) cortex, what does it contain, and receives inputs from where?
- Lies deep in the inner face of the upper bank of lateral sulcus
- Contains somatotopically representation of body surface
- Inputs arise from ipsilateral SI cortex and Ventral Posterior Inferior (VPI) of the thalamus

What inputs does the Parietal cortical somatosensory region receive, where is it located?
- Posterior to area 2, includes area 5 and area 7 (7b)
- Receives some medial lemniscal input and inputs from SI (tactile inputs)

Lesions in the parietal association area can produce what deficits?
- Agnosia
- Contralateral body parts are lost from the personal body map
- Sensation is not radically altered, but the limb is not recognized as part of the patient’s own body

The spinocerebellar pathways transmit what kind of information?
- Proprioceptive and limited cutaneous info to the cerebellum
- Includes information about limb position, joint angles, and muscle tension/length
