Lecture 2- Part I

Question 1

What is the definition of total synthesis?

Answer 1

The complete synthesis of a starting molecule from simple starting materials

Question 2

What are the cons of total synthesis ?

Answer 2

• Isolation can be time consuming and highly variable
• Large quantities of material are required to make miligrams of pure isolated product
• Access to raw materials may be restricted due to climate or political reasons

Question 3

What are the pros of total synthesis?

Answer 3

Synthesis provides reliable access to new and unnatural analogues
synthesis is amenable to scale up in order to manufacture large quantities of materials

Question 4

Why is calicheadmicin not given as a stand alone product to treat cancer?

Answer 4

it is toxic

Question 5

What should calicheadmicin be coupled with to reduce toxicity?

Answer 5

Antibody called CD33 expressed in most leukemic blasts cells