Lecture 1- Part II

Question 1

What happened in between the 1700s and 1900s?

Answer 1

• Compounds were able to be isolated
• Scientist could identify specific compounds that would be therapeutic
• Unable to identify chemical structures were mostly unknown

Question 2

What started to happen at the end of the 1800s?

Answer 2

• Basic understanding of functional group arrangement
• Structural assignment

Question 3

What is semi-synthesis?

Answer 3

Chemical derivatisation of a natural product

Relies on the ability to obtain the original precursor molecule in a pure form

By harvesting it from the plant that produces it

Then isolating it in a pure form

Question 4

Give an example of a semi-synthesis reaction

Answer 4

Morphine to heroin

Question 5

What group/family did a large proportion of medicines come from in the 1800s?

Answer 5

Alkaloids

Question 6

What are alkaloids?

Answer 6

a class of nitrogonous organic compounds of plant origin which display pronounced physiologicla action on humans

Question 7

What was the first alkaloid obtained in pure form ?

Answer 7

Morphine
in 1805
german pharmacist serturner

Question 8

What functional groups do many plant based natural products contain?

Answer 8

1. Basic amine
2. Carboxylic acid

contains either or

Question 9

Why are these functional groups useful?

Answer 9

we can exploit these functional groups to help extract them in a pure form