Lecture 2 Exam Review Week 4 Lecture Flashcards
Study of drugs that alter functions of living organisms
Pharmacology
Use of drugs to prevent, diagnose, or treat signs and symptoms and disease process
Drug therapy
Drugs given for therapeutic process derived from plants, animals, minerals, and synthetic compounds
Medications
Acts on the site of application
Local
Taken into the body and circulated via the bloodstream to sites of action, and then eliminated by the body
Systemic
Drugs are classified according to their ?
Therapeutic uses
Body Systems
Chemical Characteristics
Individual drugs that represent groups of a drug
Prototypes
CDER
FDAs Center Drug Evaluation and Research
Approves new drugs annually, approves for OTC availability, determines need for clinical trials, ensuring safety and efficacy, and black box warnings
Name legal routes of access
Prescription
OTC
Generic Name
Related to the chemical or official name, independent of manufacturer
Trade Name
Designated and partnered by manufacturer
Title II =
Controlled Substances
Comprehensive Drug Abuse Prevention and Control Act
Manufacture and distribution of narcotics, stimulants, depressants, hallucinogens, anabolic steroids
Schedule 1
No Use
ex : LSD, Ecstacy
Schedule II
High Abuse potential
ex Morphine, cocaine, meth, Phen orbital
Schedule III
Less potential for abuse
ex anabolic steroids and mixed codeine
Schedule IV
Accepted Medical Use
Benzos, phentermine
Schedule V
Moderate amounts of a controlled substance
ex Anti diarrheal and cough suppressants
ISMP
Institute for Safe Medication Practices
High Alert Meds
Pregnancy categories for Safety
BEERS Criteria
National Patient Safety Goals
TJC ( Sentinel Event 2001)
Do not use Abbreviations list
Targeted High risk activities
Cells are dynamic factories that take in?
Raw Materials
Manufacture products for the body
Differ from one tissue to another
Deliver to appropriate destination
Cells can ?
Exchange materials with immediate environment
Obtain energy from nutrients
Communicate with another via biologic chemicals
Sites of Administration
PO
GI Tract
Liver
Capillaries
Go to Bloodstream
Circulate to Target Cells
Perform Action
Return to Bloodstream
Liver- Metabolites
Bloodstream
Kidneys
Urine
Pharmacokinetics
Movement and modification inside the body
ADME
A Absorption
D Distribution
M Metabolism
E Excretion
Onset of drug action determined by the rate of absorption.
Absorption
Distribution
Carried by blood and tissue to fluids to action, metabolism, and excretion sites.
Metabolism
Method by which drugs are inactivated or Bio transformed by the body.
Drug- metabolizing enzymes are located within the kidneys, liver, RBCs, plasma, lungs, gastrointestinal mucosa.
Excretion
Elimination of medication from the body requiring adequate function of circulatory system, kidneys, BM, lungs and skin
Pharmacodynamics
Drug actions on target cells
DF
Process by which drugs alter cell physiology and affect the body.
What can turn on and off, promote or block responses that are part of the body process
DRUGS
Drugs interact with one or more cellular structures to alter cell function
Drug Receptor Interaction
Drugs may also combine with other molecules in the body to achieve their effect. True or False
True
Frequency, size, number of doses
Meet ADQ. concentration
loading doses
Maint. doses
Dosage
Route of Admin.
Influences absorption
Iv= Most effective
Name some Drug- Diet interaction examples.
Tyramine foods plus MAIOs may lead to HTN and Intracranial Hemorrhage
Green veggies vs Warfarin
Grapefruit and statins= metabolism inhibited
Additive Effects
2 similar actions
Synergism
2 Different sites = greater effects
Interference
Drugs that interfere with metabolism of each other
Displacemtn
One drug bullies another protein binding drug
ANtidote
Antagonize toxic effects
Decrease intestinal absorption
Increased rate of metabolism
Therapeutic Range
Concentration of drug in the blood serum that produces desired effect without toxicity
Peak Level
Highest Plasma Concentration
Trough Level
The point at when the drug is at its lowest concentration, and indication the rate of elimination is
Half Life
Amount of time it takes for 50% of blood concentration of a drug to be eliminated from the body.
Serum Drug Level
Laboratory Measurement of the amount of a drug in the blood at particular time which reflects
Dosage
Bioavailability
Rates of Metabolism
MEC
Min Effective Concentration
Must be present for efficacy
Toxic Concentration
Excessive Level of medication in bloodstream caused by
Single Large Dose
Repeated Small Doses
Slow Metabolism of medication
Name Some PT related Variables
Age
Weight
Genetics
Pre existing Conditions
Psycho
Developmental
Sex
Environment
Timing