Lecture 2: Animal Models Of Stroke Flashcards
1
Q
In what units is cerebral blood flow measured?
A
ml/100g/min
2
Q
Does a human brain or a rat brain have a higher cerebral blood flow?
A
Rat brain! Rats have double the CBF than humans.
3
Q
What is the average human cerebral blood flow?
A
50ml/100g/min
4
Q
What does “Flow Metabolism Coupling” refer to?
A
How the CBF must supply enough oxygen and glucose to meet the metabolic demands of the brain.
5
Q
How do cerebral blood vessels maintain CBF?
A
In response to changes in blood pressure cerebral vessels will constrict or dilate to maintain CBF.
6
Q
What is the area of potentially salvageable cells called that surround the ischaemic core?
A
The penumbra.
7
Q
What is the mechanism of death in the ischaemic core?
A
Necrosis.
