Lecture 1: Animal Models Behaviour Flashcards
1
Q
What are the three licences needed for animal research? (3Ps)
A
- Person
- Project
- Place (the establishment)
2
Q
What are the three Rs in animal research?
A
Replacement
Refinement
Reduction
3
Q
What is the difference between in vivo and in vitro?
A
In vivo is in living animals
In vitro is cells cultured in a dish
4
Q
In vitro results do not always predict results in vivo. Give an example.
A
Cytokine IL-1beta reduces neuronal damage in cultured cells but injection of IL-1beta into mouse models of stroke increases neuronal damage.
5
Q
What are the three types of validity in animal models?
A
Face validity
Construct validity
Predictive validity
