Lecture 2 (8/26) Flashcards
What are the two main organ groups of the immune system?
Primary Lymphoid and Secondary Lymphoid Organs
Which are the only WBC to possess diversity, specificity, self vs non-self recognition, and memory?
Lymphocytes
When distinguishing between CD antigens, what does the CD stand for?
Clustering Differentiation
What is the function and lymphocyte subpopulation of CD3?
signal transduction of T cell receptor/Th and Tc cells
What is the function and lymphocyte subpopulation of CD8?
adhesion molecule that binds to class I MHC molecules; signal transduction/ NK cell (variable), Tc (usually), and Th (usually)
What is the function and lymphocyte subpopulation of CD4?
adhesion molecule that binds to class II MHC molecules; signal transduction/ Th (usually) cells and Tc (usually)
Pattern Recognition Receptors are also known as what?
Toll-like receptors (TLR)
Describe what is happening.
TLR’s are specific and characteristic to some virus, bacteria, and other microbes. The pathogen is associated with molecular patterns. TLR’s recognize LPS but not specific bacteria and send signals from the outside of the cell wall to alter transcription.
Describe what is happening.
Binding by PRR of microbial structures will trigger cascading events that lead to a proinflammatory response.
Describe what is happening.
Dendritic and T cells send messages to each other
What is inflammation induced by?
tissue damage
What is inflammation characterized by?
vasodilation; increased vascular permeability; influx of WBC including phagocytes
What chemical mediators are influenced by inflammation?
substances released from the body, affected cells, certain proteins in plasma, WBC’s, acute phase proteins, histamine, kinins, others
Margination?
the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection
Diapedesis?
the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation
