Lecture 2 Flashcards
What feature of cells is essential for the normal development, growth and repair of organs and how is this achieved
Tissue homeostasis - achieved by a balance of new cell formation and knowledge of how many cells are required by a tissue and when it needs to build more
What are the effects of disruption of tissue homeostasis
Contributes to ageing and degeneration
What are the four processes underlying development
Pattern formation, morphogenesis, cell differentiation and growth
What is meant by pattern formation
The organisation of cells within the body and how they occupy particular points in the xyz axis
What is meant by the term morphogenesis
The creation of shape
Outline the process of morphogenesis
How a cell/organ/tissue adopts a particular 3D shape and how cells move and reorganise during development to generate functional organisms
What four attributes of cells determines morphogenesis
Adhesion, migration, death and shape
Define cell differentiation
The process by which cells become different from one another and acquire specialised properties
What governs differentiation
Changes in gene expression which dictate the repertoire of proteins synthesised by a cell
Differentiation is an increase in cell fate and specialisation over time that corresponds to a decrease in pluripotency, T or F
F - differentiation is a gradual restriction in cell fate over time whereby specialisation increases and pluripotency decreases
What attributes of cells in development contributes to growth or a tissue/organ
Cell proliferation, enlargement and accretion
What is meant by cell accretion
Growth of a tissue/organ that occurs by a gradual accumulation of additional layers of cells
