Lecture 2 Flashcards
0
Q
Motulsky
A
Adverse reactions are due to genetics and partly determined variations parameters
1
Q
Pharmacogenetics
A
Kinetics of handling of individual drugs differed amount individuals and populations
2
Q
Vogel
A
Termed “pharmacogenetics” and pharmacogenomics
3
Q
Vessel and Page
A
Drug half lives depend upon the drug and the population
4
Q
Metabolic ratio
A
Ration of parent drug to metabolite
5
Q
GSH
A
Necessary for anti-oxidative properties and phase 2 conjugations to speed excretion of certain drugs
Red blood cells need NADPH in order to maintain adequate GSH levels
6
Q
Glucose-6-phosphate genetic deficiency
A
Won’t make enough NADPH so oxidants accumulate leading to the chemo lysis of red blood cells
