Lecture 19 Part 2 Flashcards
Slide 39 What is a Hematoma?
??
What is a soft cal
..
How long does it take to repair the fracture process?
..
What is the green area on slide 41?
never mind
After 6 weeks, you can see the vascularization taking place slide 42
white is the marrow
What does fracture healing require?
VEGF
Slide 43
..
What happens during the early phase of imapired healing in Osteoporotic fractures?
In normal: In osteoporotic:
What happens during the Midphase of osteoporotic fractures?
In normal: In osteoporotic:
What happens during the late phase of osteoporotic fractures?
In normal: In osteoporotic:
What is the hall mark of tumor development?
Angiogenesis
How do tumors become highly vascularized?
By using growth factors like VEGF
How doe VEGF opetate in tumor growth?
….
- In early tumor development, VEGF can help establish a new vasculature
- As the vasculature networks develops, VEGF can dontinue to help new vasculature grow…
- slide 48..
What is the role of VEGF in tumor angiogenesis?
Slide 50
Whats hapening on slide 50
slide 50
whats happening on slide 51
….
What inhibits Angiogenesis?
Enostatin and Angiostatin
What is Endo statin?
Endostatin is naturally occuring,
serves as an anti-angiogenic angent
What is Angiostatin?
38kd
is part of a bigger protein called plasmin
Plasmin itself is part of another big protein called plasminogen
How do you start from Plasminogen and get all the way to Angiostatin?
Slide 54
What are Anti-angiogenic Cancer therapies?
Slide 55
What are the side effects of using Anti-angiogenic Cancer therapies?
Where can Anti-angiogenic Cancers therapies interfere with the normal actions of VEGF?
Explain what’s happening in this slide
Endostatin Treatment
Slide 57
…
as soon as they stop treatment, the tumor reappeared
after a second round of endostatin, tumor was mininmized to the point of very little regrowth
Need to reduce tumor growth to 0?
KNOW SLIDE 58
Tyrosice activity
What is the mechanism of action of anti cancer angiogenesis inhibitors VEGF
Slide 59
What does ATP do in this slide
Slide 60
What is Macular degeneration result?
Vision loss,
center of vision field is blurry or abscent
b/c there’s a mass in the eye blocking the vision
Slide 61
What’s happened in slide 62
slide 62
slide 63
?
What is demonstrated in slide 64
VEGF is required for vascularization
What’s the monoclonal antibody therapy?
