Lecture 19 - Hematologic Malignancies

Question 1

Myeloid cell lines

Answer 1

myelodysplastic syndrome
chronic myeloid leukemia
acute myeloid leukemia

Question 2

Lymphoid cell lines

Answer 2

hodgkin lymphoma
non-hodgkin lymphoma
chronic + acute lymphocytic leukemia
multiple myeloma

Question 3

Hematopoiesis

Answer 3

blood cell production; occurs mostly in hips + sternum where bone marrow is most active
in cancer we get inhibition of differentiation, leading to uncontrolled proliferation, and then futile hematopoiesis, all lymphocytes accumulating and crowding out marrow

Question 4

What is the lymphatic system?

Answer 4

lymph nodes and lymph vessels
immune system: B and T lymphocytes
B cells attack invaders outside the cell, T cell attack infected cells

Question 5

2 major types of lymphomas

Answer 5

hodgkin lymphoma: characterized by reed-sternberg cells
non-hodgkin lymphoma: 30+ unique histopathologic diseases; generally B cell mediated
chemo is the backbone of treatment

Question 6

Hodgkin lymphoma pathophysiology

Answer 6

reed-sternberg cells: multinucleated cells, originate from B-lymphocytes
B-cell transcription disrupted: loss of immunoglobulin expression, lack of apoptosis pathwyas, proliferation of malignant cells

Question 7

Gold standard for determining hodgkin lymphoma

Answer 7

excisional lymph node biopsy