:ecture 7 - Cell Therapy

Question 1

Myeloid cellular immunotherapy

Answer 1

sipulcel-T - approved for metastatic prostate cancer

Question 2

Sipulcel-T

Answer 2

“drug” is PAP-GM-CSF, a recombinant human protein containing prostatic acid phosphatase linked to granulocyte macrophage colony stimulating factor, an immune cell activator
antigen presenting cells activated by ex vivo treatment with PAP-GM-CSF and then reinfused into individual pt
goal is to stimulate a patient’s own immune system to attack the cancer
SE: flu-like sx, increased risk of stroke

Question 3

CAR T-cell therapy

Answer 3

make CAR T cells in lab: insert gene for CAR into T cell, genetically putting in receptor that binds to cancer –> grow millions of CAR T cells –> infuse CAR T cells into patient –> CAR T cells bind to cancer cells and kill them –> remove blood from patient to get T cells

Question 4

Most CAR-T therapy targets

Answer 4

CD19