Lecture 18: Meiosis Flashcards
inhibitors of microtubules
taxol, paclitaxel, nocodazole, vinblastine (all toxic )
inhibitors of microfilaments
cytochalasin, phallodin
steps of meiosis
Interphase (G1, S, G2), Prophase 1, Metaphase 1, Anaphase 1, Telophase 1 and Cytokinesis 1, Prophase 2, Metaphase 2, Anaphase 2, Telophase 2 and Cytokinesis 2
Meiosis I is like
the business side of meiosis (separating homologous chromosomes)
Meiosis II is like
mitosis (separating sister chromatids)
Prophase I (Meiosis)
Centrosome movement along with spindle fiber formation
- Nuclear envelope dissolves
- Chromosomes condense
- Homologous chromosomes pair up and cross over genetic material
- Microtubules attach to kinetochores of each homologous pair (move them to methaphase plate)
Metaphase I (Meiosis)
Tetrads are lined up (homologous chromosomes) at the metaphase plate; Spindle fibers attach
- independent assortment
Anaphase I (Meiosis)
Homologous chromosomes separate
Telophase I (Meiosis)
Cytoplasm divides, 2 daughter cells are formed (nucleus forms), chromosomes condense and nuclear envelope forms
Cytokinesis I
cell separates into two cells
Prophase II
spindle forms
Metaphase II
still 2 chromosomes, 2 chromatids align at metaphase plate
Anaphase II
splitting of chromatids (not sisters)
homologous chromosomes
same size, contain genes at same location in the chromosome
sister chromatids
replicated forms of a chromosome joined together by the centromere