Lecture 17- Mendelian genetics

Question 1

Allelic (genotypic) heterogeneity

Answer 1

-2 different mutant alleles at the same locus (more typical)

Question 2

Locus (genotypic) heterogeneity

Answer 2

-Mutations at two or more loci can produce the same or similar phenotypes

Question 3

Clinical (phenotypic) heterogeneity

Answer 3

• Association of more than one phenotype with mutations at a single locus
• Different diseases can occur due to mutations in the same gene

Question 4

Haldane’s rule three conditions

Answer 4

• Disease is X-linked recessive
• She just has one affected son, no affected maternal relatives
• The disease reduces fitness