Lecture 17

Question 1

What was the false idea about the human genome when it was initially sequences?

Question 2

What factors influence patterns of genetic diversity and evolution (name and explain all 5)

Question 3

Explain mutation-selection balance and selection maintaining variation on how it maintains genetic variation

Question 4

What maintains genetic variation?

Question 5

What are the two models of population genetic variations and what do they stand for

Question 6

Explain morphological and cytological approach to studying genetic diversity (pre-1966)

Question 7

Explain why selection experiments (artifical selection) were done to study genetic variation using the example of fruit flies and corn. What did these experiments show?

Question 8

Describe lewontins electrophoresis revolution as a way to quantify genetic variation (molecular approch)

Question 9

What is a monomorphic vs a polymorphic gene in protien electropheresis

Question 10

What are the advantages to studying enzyme polymorphism?

Question 11

What did the first allozyme studies indicate (mention third way genetic variation may be maintained)?

Question 12

Explain third way genetic variation may be maintained - AKA The neutral theory by Kimura

Question 13

Why do humans have such low DNA sequence diversity – use data gained from corn diversity example