Lecture 16 – Mechanism of atheroma and infarction

Question 1

atheroma

Answer 1

Degeneration of the walls of the arteries caused by accumulated fatty deposits and scar tissue and leading to restriction of the circulation and a risk of thrombosis. It can weaken the wall of the vessel and it can rupture.

Question 2

atherosclerosis 4

Answer 2

disease where plaque build up into arteries.
mediated by LDLs and Angiotensin II.
Not affected by diet, happens to everyone.
Common sites are larger arteries e.g. carotid –> brain/circle of willis.

Question 3

cOnsequences of atheroma 3

Answer 3

FC

Question 4

Systemic inflammation promotes atheroma formation 4

Answer 4

Minor inflammaroy/back ground infkam - rheumatoid artheritis
SMoking - low level inflam
Parasite infections- chronic inflam
Genetic/environmental factors - vulnerability

Question 5

angina/mi 2

Answer 5

exercise causes VD so no blood to body of heartsignal sent to brain, recognises it as pain.
Thrombosis is unpredicatble it can origniate in the heart and cause MI.

Question 6

MI diagnosis and prognosis 3

Answer 6

ST elevation - damaged tissue - ischaemic and died.
Does noT conduct electricity or depolarise.
STEMI – ST elevated myocardial infarction..

Question 7

COMPLICATIONS OF MI 6

Answer 7

• Acute cardiac failure
• Conduction problems – arrhythmia
• Papillary damage – valve dysfunction
• Mural thrombosis – stroke
• Wall rupture
• Chronic heart failure