Lecture 16: Measuring Disease Occurrence Flashcards

1
Q

What are populations?

2

A
  • A group of people in a geographical area

- A group of people with a common characteristic

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2
Q

What is first used to understand a disease in a population?

A

Measuring a diseases occurance

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3
Q

Why is the occurrence of disease measured in populations?

3

A
  • To understand health status
  • Trends in disease over time
  • How disease impacts different groups
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4
Q

What are the measures of disease occurrence?

3

A
  • Prevalence
  • Incident proportion
  • Incident rate
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5
Q

What is incident proportion sometimes referred to?

A

Cumulative incidence

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6
Q

What is prevalence?

A

The proportion of a population who HAVE the disease at a point in time

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7
Q

What does prevalence tell us?

A

The proportion of a population who have a disease at a certain point in time

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8
Q

Why do you want to consider the prevalence of a disease in a population?

A

To understand the burden of the disease and how to allocate resources

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9
Q

How do you calculate prevalence?

A

Number of people with the disease at a given point in time
/
Total number of people in the population at that point in time

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10
Q

When reporting prevalence what aspects must be expressed to interoperate findings?
(5)

A
  • Measure of occurrence
  • Exposure or outcome
  • Population
  • Time point
  • Value
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11
Q

What are 2 limitations of prevalence?

A
  • Difficult to assess the development of disease

- It is influenced by the duration of the disease

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12
Q

How does duration influence prevalence?

A

At a given time the prevalence can be higher due to cases lasting longer with out there being an actual higher amount of cases throughout the study

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13
Q

What is incidence?

A

The occurrence of NEW CASES of an outcome in a population during a specific period of follow-up

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14
Q

What is incidence proportion?

A

The proportion of an outcome-free population that develops the outcome of interest in a specific time period

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15
Q

How do you calculate incidence proportion?

A

Number of people who develop the disease in a specified period
/
Number of people at risk of developing the disease at the start of the period

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16
Q

What are reasons people are not considered to be at risk at the start of a study?
(2)

A
  • They already have the condition

- The condition is something that they cannot develop

17
Q

When reporting incidence proportion what aspects must be expressed to interoperate findings?
(5)

A
  • Measure of occurrence
  • Exposure or outcome
  • Population
  • Time point
  • Value
18
Q

Why is incident proportion used?

A

It shows the average risk amongst a population, but not of each individual

19
Q

What are limitations of incidence proportion?

2

A
  • Assumes a ‘closed’ population (does not account for people coming or going in populations)
  • Highly dependent on the time period (longer time period = higher incidence proportion)
20
Q

What is incidence rate?

A

The rate at which new cases of the outcome of interest occur in a population

21
Q

How do you calculate incidence rate?

A

Number of people who develop the disease in a specified period
/
Number of person-years at risk of developing the disease

22
Q

What are person-years at risk of developing a disease?

A

The sum of everyone in the population’s time at risk of becoming a case

23
Q

Why might someone stop being at risk of disease?

A
  • They become a case
  • They are lost to follow-up
  • Follow-up time ends
24
Q

When reporting incidence rate what aspects must be expressed to interoperate findings?
(4)

A
  • Measure of occurrence
  • Exposure or outcome
  • Population
  • Value
25
Q

What are limitations of incidence rate?

A

Information needed to calculate is often difficult to attain and complex to calculate

26
Q

What does prevalence approximate?

A

Incidence X average disease duration

27
Q

What ca changes to incidence and duration alter?

A

Disease prevalence

28
Q

When comparing populations can disease be affected by age?

A

Yes

29
Q

When comparing populations do age structures often differ?

A

Yes

30
Q

What does age standardisation do?

A

Removes the effects of populations having different age structures

31
Q

When is age standardisation used?

A

When age structures differ in each population and disease risks vary by age