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Biochemistry 1 BB10003 > lecture 15 - pyruvate dehydrogenase complex > Flashcards

lecture 15 - pyruvate dehydrogenase complex Flashcards

1
Q

what does glucose convert to in glycolysis?

A

2 pyruvates and generating 2 ATPs and 2 NADH plus H plus

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2
Q

How can NAD regenerate?

A

In the presence of oxygen

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3
Q

What happens in an oxygen debt?

A
  • bacteria and yeast can grow

- humans enter an oxygen debt

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4
Q

what happens to humans in a oxygen debt?

A

pyruvate to lactate

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5
Q

what happens to yeast in an oxygen debt?

A

pyruvate to ethanol to ethanol

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6
Q

What are the substrates needed in the pyruvate dehydrogenase complex?

A

pyruvate, CoA and NAD plus

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7
Q

What are the products produced in the pyruvate dehydrogenase complex?

A

Acetyl - SCoA and CO2 and NADH and H plus

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8
Q

What does TPP stand for?

A

Thiomin pyrophosphate

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9
Q

What does E1 stand for?

A

pyruvate decarboxylase

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10
Q

What dos E2 stand for?

A

lipoyl acetyl transferase

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11
Q

What does E3 stand for?

A

dihydrolipoamide dehydrogenase

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12
Q

what does the cofactor FAD stand for?

A

Flavinadenine dinucleotide

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13
Q

What molecule can communicate with E1, E2,E3?

A

Lipoic acid

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14
Q

How can Lipoic acid communicate with E1 , E2 and E3?

A

It has a swinging arm which is made up of lysine and lipoid acid

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15
Q

What is the structure of the PDHC in prokaryotes ?

A

It is made up of cube of E2 enzymes, with E1 and E3 stuck on the surface

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16
Q

What is the ratios and number of all the enzymes on the PDHC in prokaryotes ?

A

48 E1 : 24 E2: 24E3

96 globular proteins in total

17
Q

What is the structure of the PDHC in Eukaryotes ?

A

pentagonal dodecahedron

18
Q

How many E2s are there in a PDHC eukaryote?

A

60 copies

19
Q

What is pyruvate converted into?

A

hydroxyethyl - TPP

20
Q

What us hydroxyethyl-TPP converted into?

A

Acetyl- dihydrolipoamide

Biochemistry 1 BB10003 (18 decks)

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