Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BC4009 > Lecture 15 (nuclear oncoproteins) > Flashcards

Lecture 15 (nuclear oncoproteins) Flashcards

1
Q

Examples of nuclear oncoproteins

A

Jun, Fos, ATF, Maf, CREB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the viral ErbA oncogene?

A

A gag fusion protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is ErbA?

A

Thyroid hormone receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What does ErbA do?

A

Blocks differentiation of erythroblasts to erythrocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Does ErbA cause transformation?

A

Not by itself, but it enhances the ability of ErbB to cause transformation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Can the ErbA oncogene still bind the thyroid response element?

A

Yes, but has lost the ability to bind the thyroid hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

ErbA has sequence homology to…

A

steroid hormone receptors (particularly DNA binding region)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Jun oncogene was isolated in __

A

ASV-17 virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Fos oncogene was isolated in __

A

FBJ-MuSV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What transcriptional regulator do both jun and fos show sequence homology to?

A

GCN4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Jun and Fos form a complex which binds DNA called the __ complex

A

AP-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What region of the AP-1 complex links proteins?

A

Leucine zipper region

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Jun dimerisation

A

can dimerise with itself or with fos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

True or False: Fos alone does not form dimers nor bind DNA.

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which are more effective: jun/fos heterodimers or jun homodimers?

A

jun/fos heterodimers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The classical AP-1 complex comprises __ and __

A

c-jun and c-fos

17
Q

Jun and fos transcriptional activators act in response to which two pathways?

A

PKC and Ras

18
Q

MAPK phosphorylating c-jun increases the ability of c-jun to…

A

interact with c-fos

19
Q

How can AP-1 activity be regulated?

A

by dimer composition, transcription, PTM, interactions with other proteins

20
Q

True or False: AP-1 has both oncogenic and anti-oncogenic effects.

A

True

21
Q

__ is upregulated by AP-1, increasing cell growth and proliferation

A

EGFR

22
Q

Functions of myc

A
  • regulate gene transcription
  • cell cycle progression
  • cooperate with Ras mutations
  • involved in chromosomal translocation in some cancers
23
Q

Myc proteins are localised in the __

A

nucleus

24
Q

Myc transcription factor functions as a __

A

complex/heterodimer

25
Q

Which signalling pathway leads to the upregulation of c-myc?

A

Oestrogen

26
Q

Myc shows homology to…

A

DNA binding regions of GCN4, fos & jun

27
Q

Myc associates with the __ protein

A

max

28
Q

How does the myc/max complex regulate transcription?

A

by binding to CACGTG sequences

29
Q

Myc/max interaction is regulated by __

A

phosphorylation

30
Q

Important event in development of Burkitt’s lymphoma in subtropical Africa

A

myc translocating into the immunoglobulin locus

BC4009 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions