Lecture 15

Question 1

True or false: FeLV is a retrovirus. All retroviruses contain reverse transcriptase

Answer 1

True

Question 2

Who does FeLV infect?

Answer 2

Any cat, but chances increase with male cats, cats that live outside, and cats in close contact with other infected cats

Question 3

Retrovirus is a subfamily of…

Answer 3

Oncovirinae

Question 4

When testing for FeLV, what are antigen do we test for?

Answer 4

P27 Ag

Question 5

True or false: FeLV is sensitive to heat, UV light, and dehydration

Answer 5

True

Question 6

Can FeLV survive outside the host?

Answer 6

No; it can be killed by ordinary household/hospital detergents and bleach

Question 7

How long will FeLV not survive unless it is wet

Answer 7

3-4 hours

Question 8

Modes of transmission of FeLV

Answer 8

Licking, grooming, biting, tears, blood, semen, vaginal secretions, and milk

Question 9

How is FeLV spread other than physical contact?

Answer 9

Fomites

Question 10

True or false: a waiting period is not needed to introduce new cats into the household, but there should be no new cats in a FeLV positive hose

Answer 10

True

Question 11

How can kittens get FeLV?

Answer 11

Before birth or from licking and drinking milk

Question 12

True or false: 80-85% of infected healthy cats will be dead withing 1-2 years from time of original diagnosis

Answer 12

False; 3-4 years

Question 13

The use of the cats DNA to make more of the FeLV virus

Answer 13

Active infection

Question 14

Integrates itself into the hosts cell and sits there and does nothing

Answer 14

Latent infection

Question 15

Gets into oncogene and turns it on, resulting in transformation

Answer 15

Insertional Mutagenesis

Question 16

Phase 1 of FeLV involves…

Answer 16

The oropharynx and the tonsils

Question 17

True or false: once a cat is in phase 2 of FeLV, it is reversable

Answer 17

False; it is non-reversable

Question 18

With phase 1 FeLV, what will be the result of an ELISA and IFA be?

Answer 18

Negative

Question 19

In phase 2 FeLV…

Answer 19

The virus spreads to systemic lymphoid tissue, BM, and intestine

Question 20

With phase 2 FeLV, what will the result of an ELISA and IFA be?

Answer 20

Positive

Question 21

IFA test detects…

Answer 21

The presence of virus particles within WBC

Question 22

What percentage of cats are in the progressive stage of FeLV?

Answer 22

30%

Question 23

What percentage of cats are in the regressive stage of FeLV?

Answer 23

35%

Question 24

What percentage of cats are in the abortive stage of FeLV?

Answer 24

35%

Question 25

Seroconversion

Answer 25

When specific AB develops and becomes detectable in the blood

Question 26

What percentage of cats that are infected with FeLV develop non-neoplastic disease and die within 3 years?

Answer 26

70%

Question 27

What percentage of cats that are infected with FeLV will die of neoplasia?

Answer 27

30%

Question 28

Disease associated with FeLV

Answer 28

Gingivitis and a persistent fever

Question 29

Most common neoplasia of FeLV

Answer 29

Mediastinal lymphosarcoma

Question 30

IFA

Answer 30

Used to confirm ELISA results

Question 31

Cats that test positive and live as a single cat household…

Answer 31

Should be housed inside only, do not need the vaccine, need regular checkups, and manage the symptoms

Question 32

What antibody does the FeLV vaccine contain? Does vaccination interfere with testing?

Answer 32

GP70; no