Lecture 14: Growth, Puberty and Psychiatric Problems Flashcards

1
Q

what assessment tools are used to assess normal growth and pubertal development?

A
  • height/length/weight
  • growth charts and plotting
  • MPH and target centiles
  • growth velocity
  • bone age
  • pubertal assessment (e.g. Tanner)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

describe the Tanner method for staging of puberty

A
  • B: 1-5 (breast development)
  • G: 1-5 (genital development)
  • PH: 1-5 (pubic hair)
  • AH: 1-3 (axillary hair)
  • T 2ml to 20ml (testicle volume)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what measurement tool is used for testicular volume?

A

Prader Orchidometer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

list the factors influencing height

A
  • age
  • sex
  • race
  • nutrition
  • parental heights
  • puberty
  • skeletal maturity (bone age)
  • general health
  • chronic disease
  • specific growth disorders
  • socio-economic status
  • emotional well-being
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are the most important and earliest objective signs of puberty?

A
  • breast budding (Tanner stage B2) in a girl
  • testicular enlargement (Tanner stage G2-T 3-4ml) in a boy
  • earliest objective signs of puberty and when present puberty will usually progress onwards
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

list the indications for referral in suspected growth disorders

A
  • extreme short or tall statures (off centiles)
  • height below target height
  • abnormal height velocity (crossing centiles)
  • history of chronic disease
  • obvious dysmorphic syndrome
  • early/late puberty
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what are common causes of a short stature?

A
  • familial
  • constitutional (delayed puberty)
  • being born small for gestation age (SGA)/intrauterine growth retardation (IUGR)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

list the pathological causes of short stature

A
  • undernutrition
  • chronic illness (JCA, IBD, Coeliac)
  • iatrogenic (steroids)
  • psychological and social
  • hormonal (GHD, hypothyroidism)
  • syndromes (Turner, Prader-Willi, Noonan’s)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is considered early puberty in boys?

A

< 9 years old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is considered delayed puberty in boys?

A

> 14 years old (common, especially constitutional delay of growth and puberty (CDGP))

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is considered early puberty in girls?

A

< 8 years old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is considered delayed puberty in girls?

A

> 13 years old (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is central precocious puberty?

A
  • refers to premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, resulting in early puberty.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what investigations are performed for suspected central precocious puberty?

A

Girls:
- usually idiopathic
- pituitary imaging

Boys:
- look for underlying cause i.e. brain tumour?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the treatment for central precocious puberty?

A

GnRH agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

list features of precocious pseudopuberty

A
  • Gonadotrophin independent (low/prepubertal levels of LH and FSH)
  • abnormal sex steroid hormone secretion
  • virilising or feminising
  • clinical picture: secondary sexual characteristics
17
Q

what is the management approach for a baby born with ambiguous genitalia?

A
  • do not guess the sex of the baby!
  • multidisciplinary approach (paed endo, surgery, neonatologist, geneticist, psychologist)
  • exam: gonads?/internal organs
  • karyotype
  • exclude congenital adrenal hyperplasia!
18
Q

features of congenital hypothyroidism

A
  • 1 in 4000 births
  • causes: athyreosis/hypoplastic/ectopic or dyshormonogenic
  • newborn screening
  • start treatment within first 2 weeks
19
Q

which drugs can increase risk of obesity?

A
  • insulin
  • steroids
  • antithyroid drugs
  • sodium valproate
20
Q

which syndromes can cause obesity?

A
  • prader-willi syndrome
  • laurence-moon-biedl syndrome
  • pseudohypoparathyroidism type 1
  • down’s syndrome