Lecture 14. Glycogenolysis and Glycogen Synthesis

Question 1

What happens in McCardle disease ?

Answer 1

Not able to mobilise glycogen in muscle

Question 2

What happens in Pompe disease ?

Answer 2

Accumulation of glycogen in lysosomes

Question 3

What are some human disorders of glycogen metabolism ?

Answer 3

1. Von Gierke disease

2. Pompe disease

Question 4

What is the function of adrenalin in glycogenolysis and glycogen synthase ?

Answer 4

Switches on glycogenolysis and switches off glycogen synthase

Question 5

What is the primer for glycogen synthase ?

Answer 5

Glygogenin

Question 6

What is the key enzyme in glycogen synthesis ?

Answer 6

Glycogen synthase

Question 7

What activates glucose ?

Answer 7

UDP

Question 8

What does UDP stand for ?

Answer 8

Glucose pyrophosphatase

Question 9

What needs to happen to glucose before it can be incorporated into glycogen ?

Answer 9

Needs to be activated

Question 10

What is a major trigger of glycogenolysis ?

Answer 10

Adrenaline (epinephrine)

Question 11

What is phosphorylase ?

Answer 11

A dimer that exists in four states. It is covalently modified by phosphorylase kinase

Question 12

Where is glycogen stored ?

Answer 12

The liver and skeletal muscles

Question 13

What is glycogen ?

Answer 13

The storage form of glucose