Lecture 14 - Enzymes IV - Regulation Flashcards
1
Q
What types of influence control exist in regulation of enzyme activity?
L14 S3
A
Substrate level:
- only involves as single reaction
- product regulates its own reaction
Feedback control:
- controls a different step in the pathway
- product regulates a different reaction
2
Q
What common modifications are used in regulation of enzyme activity?
L14 S7-12
A
Lipids:
- Myristic acid
- farnesyl
Nucleic acids:
- ADP-ribose
- NAD+
Proteins:
-ubiquitination
Carbohydrates:
- N-linked/O-linked
- composition of sugar
- branched/unbranched
- length
Small molecules:
- γ-carboxylation
- sulfination
- acetylation (typically activating)
- methylation (either/or)
- phosphorylation (typically activating)
3
Q
What is an example of irreversible modification that regulates enzyme activity?
L14 S28
A
Proteolytic activation; conversion of zymogen to active enzyme
