Lecture 14 Flashcards
1
Q
How are mt proteins made in the cytosol targeted to the mt?
A
using a LP
2
Q
Describe the structure of LPs
A
Amphipathic
Helical
18-80 amino acids
3
Q
TOM complexes
A
import receptors
LPs are recognised by TOM complexes and pass through a transport channel formed by Tom40
4
Q
At rare contact sites what occurs?
A
A channel is formed by Tim23 and Tim17 proteins
5
Q
What does Tim mediated transport require?
A
Proton motive force (a combination of electric potential and pH gradient) and consumption of ATP by a mt matrix Hsp70 family member (motalin)
6
Q
what is the mtHsp70 protein?
A
mortalin
7
Q
which protein is targeted to the matrix
A
alcohol dehydrogenase
8
Q
which protein is target to the inner membrane
A
cytochrome b2
cytochrome oxidase CoxVa
9
Q
which protein is targeted to the outer membrane
A
P70
