Lecture 12 - Parkinson's disease Flashcards
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3
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4
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Accumulation of proteinaceous aggregates (Lewy Bodies) containing α synuclein
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6
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7
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8
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The effort of movement, its initiation and its termination
http://www.youtube.com/watch?v=lGKxaF4oXb0
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11
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PD: from mitochondrial dysfunction to neuronal degeneration
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12
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13
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Fission:
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occurs to protect function by facilitating equal segregation of mitochondria into daughter cells
to improve distribution of mitochondria along microtubules tracks
to isolate segments of damaged mitochondria, promoting their clearance by macroautophagy
14
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Fusion:
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A mechanism required for the proper respiratory activity,
metabolic efficiency of mitochondria
for the stabilization, and protection of mitochondrial integrity
15
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Impaired mitochondrial turnover in PD
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17
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22
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24
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