Lecture 10 - Alzheimer's disease Flashcards
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Autophagy failure in Alzheimer’s Disease
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Presence of neurofibrillary tangles, dystrophic neurites, senile plaques
Dystrophic swellings filled mainly with autophagic vacuoles, multilamellar bodies and autophagolysosomes
Defective autophagy in AD
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Autophagy pathology in AD
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Autophagosomes can also fuse with endosomes, forming an amphisome.
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Autophagy pathology is extensive in AD
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High density of senile plaques. Dystrophic neurites contain hundreds of AV.
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