Lecture 12 Objectives Flashcards

1
Q

What is the saccadic hierarchy from low to high?

A
Quick phases of VOR/OKN
Visually guided (reflexive saccades)
Volitional saccades (1-4)
1. to command
2. Predictive, anticipatory
3. Memory guided
4. Antisaccades
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2
Q

What are the five characteristics of saccades?

A
Latency
Velocity
Duration
Amplitude
Accuracy
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3
Q

What is normal latency of saccades?

A

200msec, +-50

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4
Q

What things affect latency?

A

Patient motivation
Attention
Target predictability

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5
Q

What is the normal velocity range for saccades?

A

30-700 degrees per second

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6
Q

What is the max speed of saccades?

A

1000 degrees per second

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7
Q

Peak velocity of saccades increases with what?

A

Amplitude

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8
Q

What is the normal duration of saccades?

A

30-100msec

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9
Q

Duration of saccades increases with what?

A

Amplitude

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10
Q

Which two characteristics of saccades demonstrate a main sequence relationship?

A

Velocity

Duration

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11
Q

What is the normal amplitude for saccades?

A

Less than 15 degrees

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12
Q

Gaze changes larger than 15 degrees usually stimulate what?

A

Head movement as well as saccadic eye movement

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13
Q

How is accuracy of saccades described?

A

Hypometria

Hypermetria

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14
Q

When does hypometria tend to occur?

A

With large amplitude saccades

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15
Q

When does hypermetria tend to occur?

A

With small amplitude saccades

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16
Q

Hypometria is usually less than __% of the overall amplitude.

A

10%

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17
Q

If there is a lesion in the fastigial nuclei, what type of saccades will most likely be seen?

A

Hypermetric saccades

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18
Q

With age, what happens to saccadic latency?

A

Increases by 1-2msec per year

19
Q

With age, what happens to saccadic peak velocity?

A

Decreases by 1 degree per second, per year

20
Q

With age, what happens to saccadic gain and accuracy?

A

They don’t change with age

21
Q

What may reduce saccadic gain and accuracy?

22
Q

What is the saccadic pulse?

A

A phasic muscle contraction that moves the eye rapidly against the orbital tissues

23
Q

What is a saccadic step?

A

A tonic muscle contraction to hold the eye steady at its new position

24
Q

What determines saccadic velocity?

A

Pulse innervation - the higher frequency of firing causes faster movement

25
What are the three important neurons in the saccadic pulse generator?
Motor neurons Burst neurons Omnipause neurons
26
In saccades, where does the signal for horizontal movement begin?
Burst neurons in PPRF
27
In saccades, where doe the signal for vertical movement begin?
Burst nurons in the riMLF
28
Where are omnipause neurons located?
Raphe Interpositus (RIP)
29
What inhibits both horizontal and vertical burst neurons?
Omnipause neurons
30
What is the neural integrator (NI) for horizontal saccades?
Nucleus Prepositus Hypoglossi and Medial Vestibular Nucleus (NPH-MVN)
31
Where is the NPH-MVN located?
Medulla
32
What is the neural integrator (NI) for the vertical and torsional saccades?
Interstitial Nucleus of Cajal (INC)
33
Where is the INC located?
Midbrain
34
What is the effect of a lesion of the PPRF?
Slow or absent horizontal saccades to the same side
35
What is the effect of a lesion of the riMLF?
Slow or absent vertical saccades
36
What is the effect of a lesion of the RIP?
Disruption of omnipause neurons, leading to saccadic oscillation like opsoclonus and flutter Slow saccades
37
What is the effect of a lesion of the NPH-MVN?
Horizontal gaze-evoked nystagmus due to failure of gaze holding
38
What calculates egocentric direction?
Posterior Parietal Cortex (PPC)
39
What do the parietal eye fields (PEF) do?
Initiate reflexive, visually guided saccades
40
What initiates voluntary saccades?
Frontal eye fields (FEF)
41
What does the superior colliculus control?
Saccade trajectory
42
What is the pathway of reflexive saccades?
V1 PEF SC Brainstem saccade generator
43
What is the pathway of voluntary saccades?
V1 FEF SC Brainstem saccade generator