Lecture 12 Microbial Mechanisms of Pathogenicity Flashcards
1
Q
Pathogenicity
A
ability to cause disease
2
Q
virulence
A
degree of pathogenicity
3
Q
Portals of Entry
A
- mucous membranes
- skin
- parenteral route
4
Q
ID50
A
- infectious dose for 50% of a sample population
- measures virulence of a microbe
5
Q
LD50
A
- lethal dose of 50% of a sample population
- measures potency of a toxin
6
Q
Adherence
A
process of pathogens attaching to host tissues
7
Q
Adhesins
A
- on a pathogen
- bind to receptors on host cells
8
Q
What are receptors typically made of?
A
mannose
9
Q
Capsule
A
- glycocalyx around cell wall
- impair pgahocytosis
10
Q
M protein
A
resist phagocytosis
11
Q
Opa
A
protein that allows attachment to host cells
12
Q
Waxy Lipid
A
- mycolic acid
- resists digestion
13
Q
Coagulases
A
coagulate fibrinogen
14
Q
Kinases
A
digest fibrin clots
15
Q
Portals of exit
A
how pathogens exit from host to enter new host
- resp. tract
- gastrointestinal tract
- genitourinary tract
- skin
- blood
