Lecture 12 Lymphomas

Question 1

What is the difference between Hodgkin Lymphoma and Non-Hodgkin Lymphoma based on the peripheral blood?

Answer 1

Hodgkin Lymphoma - peripheral blood is never involved.

Non-Hodgkin Lymphoma - Peripheral blood may be involved

Question 2

Which type Hodgkins or Non-Hodgkins may have possible bone marrow involvement?

Answer 2

Hodgkin’s is localized with contiguous spreading in a predicable pattern, primarily a nodal disease and never in the bone marrow with abnormal cells.

Question 3

Which type Hodgkins or Non-Hodgkins has Reed-Sternberg cells?

Answer 3

Hodgkin Lymphoma.

Malignancy most often of lymph nodes characterized by presence of Reed Sternberg cells and variants of with a background of varying numbers of benign lymphocytes, plasma cells, histocytes, and eosinophils.

Question 4

There are various morphologies of Reed-Sternberg cells, describe the most typical one described in literature?

Answer 4

Typical Reed-Sternberg cell in literature is 2 cells resembling owl eyes.

Question 5

What type of cells may be found in the circulating blood in Non-Hodgkin Lymphoma?

Answer 5

Lymphoma cells may be found in circulating blood in Non-Hodgkin Lymphoma.

Cells may be present in bone marrow and peripheral blood.