Lecture 12 Cerebral Blood Flow: Effects Of Exercise And Ageing

Question 1

Which of the following is not a key regulator of cerebral blood flow?

a) PaCO2
b) Cerebral perfusion pressure
c) Cerebral metabolism
d) Acetylcholine

Answer 1

d) Acetylcholine

Question 2

Which of the following statements best describes the influence of exercise on cerebral blood flow (CBF)?

a) Increases in exercise intensity up to 60% VO2max produce elevations in CBF, after which BF decreases towards baseline values despite further increases in exercise intensity and brain metabolism
b) Cerebral blood flow increases in direct proportion to exercise intensity, with the greatest levels of CBF evident during maximal exercise.
c) Cerebral blood flow remains stable at all intensities of exercise.
d) Cerebral blood flow declines as exercise intensity increases in order to distribute more blood to the
working muscles.

Answer 2

a)
Increases in exercise intensity up to 60% VO2max
produce elevations in CBF, after which BF decreases
towards baseline values despite further increases in
exercise intensity and brain metabolism

Question 3

What happens to resting cerebral blood flow and cerebral oxygenation (expressed relative to brain mass) across the lifespan?
a) Cerebral blood flow and oxygenation are stable through the lifespan and only decline when an individual is suffering from disease.
b) Cerebral blood flow and cerebral oxygenation are at their greatest during childhood, but they rapidly decline until
puberty, after which there is a more gradual decline across the remaining age span.
C) Cerebral blood flow and cerebral oxygenation increase with advancing age and increases in body mass.
d) Changes in cerebral blood flow and cerebral oxygenation across the lifespan follow an inverted-U pattern in which they are highest during childhood and old age.

Answer 3

b) Cerebral blood flow and cerebral oxygenation are at their greatest during childhood, but they rapidly decline until
puberty, after which there is a more gradual decline across the remaining age span.

Question 4

Which of the following changes
to homeostatic processes is not
associated with ageing?

a) Loss of cutaneous
receptors
b) Small changes in the
target set point
c) Decreased time to
respond and equilibrate
d) Deterioration of the
function of effectors

Answer 4

c) Decreased time to respond and equilibrate