Lecture 12 Blood Flashcards
What is blood
Fluid Connective Tissue
What does blood contain ?
Plasma and Formed Elements
What is the function of Blood?
- Transportation: Nutrients, wastes, gasses, horomones
- Regulation: Body temperature, PH , Fluid volume
- Protection: Immune system
What is Blood Composition after centrifugation?
- Plasma (55%)
- Buffy Coat (1%)
- Erythrocytes (44%)
what are the main characteristics of Plasma ?
it makes up 55% of blood and straw colored fluid , contains proteins
what proteins found in plasma ?
- Albumin
- Globulin
- Fibrinogen
- Regulatory Proteins
Albumin
Abundance of 58% (majority)
osmotic regulation
transport ions and hormones
Globulin
Abundance of 37%, and contains 3 types
- Alpha: protect lipids
- Beta: Protects lipids
- Gamma: Antibodies
Fibrinogen
Abundance is 4%
blood clot formation
Regulatory Proteins
Abundance 1%
Enzymes and hormones
Formed Elements
- Erythrocytes
- Leukocytes
- Platelets
Erythrocytes
Red blood cells
What are the characteristics of Erythrocytes
44% blood
lack nuclei and organelles
biconcaved
contains hemoglobin (gas transport)
What is the structure of Hemoglobin?
red pigmented protein
4 globin proteins (2 alpha chains, 2 beta chains)
4 heme groups Fe+ (FE+ is Iron) Wharegroup for each globin
What is the function of hemoglobin?
Transportation O2 and CO2
o2 can bind to each heme group –> 1 hemoglobin can transport 4 O2
what is the erythrocyte life cycle ?
- Formed in red bone marrow
- circulation 120 days
- recycled by liver and spleen ( think spliver)
Heme –> billirubin–> bile (;iver will breakdown heme)
–billirubin= precursor to bile
Iron –> red bone marrow (Red bone marrow produces new blood cells)
Proteins and membranes –> free amino acids
what are Red Blood cells in reference to hemoglobin
RBC’s are sacs of hemglobin
What is the main protein found in RBC
Hemoglobin
Why are Erythrocytes (RBC) red
Because they have a portion of iron in them and Iron has a red pigementation to it
what does hemoglobin bind to ?
binds to CO2 and O2