Lecture 12: Bariatrics & Hernias Flashcards
Which hormone is known as the satiety hormone? Where is it produced?
Leptin - produced in adipose tissue, inhibits hunger
How is leptin altered in obesity?
Increased production but decreased sensitivity - dont feel full
Which hormone is known as the hunger hormone because it stimulates hunger? Where is it produced?
Ghrelin - (stomach goes Grrr when hungry)
- produced in fundus
How does Ghrelin differ from Leptin?
Ghrelin opposes Leptin and it doesn’t affect satiety
How does insulin affect leptin?
insulin blocks leptin in the brain causing increased hunger
What hormone increases satiety?
Peptide YY
What hormone increases insulin sensitivity and decreases energy storage and hunger?
GLP-1
What are the top 2 consequences of obesity?
- DM
2. HTN
What is obesity the single most reliable predictor of?
Type 2 DM
For each 1% of body wt lost, how is your DBP and SBP affected?
lose 1% body wt:
- 1 mm Hg decrease in DBP
- 2 mm Hg decrease in SBP
For BMI >35 what is the only method for sustained wt loss?
Surgery
note: surgery is ToC when BMI > 40
Bariatric surgery is what type of wound classification? And therefore what ABX should be used?
Clean contaminated - use Cefazolin or Clindamycin
What are the components of the NIH criteria for bariatric surgery?
- BMI > 40 or BMI > 35 + comorbid illness
- Hx of failed sustained wt loss on a supervised wt reduction program
- No substance abuse, psychoses or uncontrolled depression
What is the purpose of malabsorptive bariatric procedures? Example?
They shorten the digestive tract
Ex: BPD
What is the purpose of restrictive bariatric procedures? Examples?
Reduce the amount of food the stomach can hold
Ex: Sleeve Gastrectomy, Gastric Band surgery
What is the gold standard bariatric procedure?
Sleeve gastrectomy
What parts of the stomach are kept and removed in Sleeve gastrectomy? Results in?
Keep antrum - limits food intake
Remove fundus
Result: smaller stomach –> produce no ghrelin, faster transit time –> more insulin sensitivity & satiety
Advantages of sleeve gastrectomy?
what is the main disadvantage?
- Laproscopic
- **No rerouting of GI tract (no defic)
- **Eliminate hunger hormone
- Fewer complications than bypass
- Fairly rapid initial wt loss
Disadv: NOT reversible