Lecture 12

Question 1

CaO2 equation

Answer 1

(Hb x 1.34 x SaO2) + (PaO2 x 0.003)

Question 2

a-vO2diff equation

Answer 2

CaO2-CvO2

Question 3

What percent (%) of CO2 in the blood travels as bicarbonate?

Answer 3

70%

Question 4

Oxyhemoglobin dissociation curve left vs right shift

Answer 4

Left shift: O2 affinity higher, offloading lower
Right (Bohr) shift: O2 affinity lower, offloading higher

Question 5

Does O2 offload from Hb faster at high or low PO2?

Answer 5

Offloading is faster at low PO2

Question 6

PvO2 during exercise

Answer 6

Decreases from 40mmHG to 30mmHg
(greater a-vO2diff)

Question 7

When/why does a Bohr shift occur with the oxyhemoglobin dissociation curve

Answer 7

During exercise:
Higher CO2 levels from exercise reduce Hb’s affinity to O2

Question 8

Haldane effect (CO2)

Answer 8

When O2 is high (at lungs), CO2 pickup is lower
When O2 is low (at tissue), CO2 pickup is higher