Lecture 11: Part 4 (Basic Mechanisms of Antibiotics)

Question 1

Antibiotics that \_\_\_\_\_\_\_\_ inhibit DNA gyrase (enzyme responsible for supercoiling, nicking, and sealing bacterial DNA).
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 1

B.) inhibit nucleic acid synthesis

Question 2

Antibiotics that \_\_\_\_\_\_\_\_ block ribosomes (both the 30S and 50S subunits) and result in the misreading of mRNA.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 2

D.) inhibit protein synthesis

Question 3

Antibiotics that \_\_\_\_\_\_\_\_ have selective toxicity.  
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 3

A.) inhibit cell wall synthesis

Question 4

Antibiotics that \_\_\_\_\_\_\_\_ compete with PABA for active site on an enzyme.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 4

C.) target metabolic pathways

Question 5

Antibiotics that \_\_\_\_\_\_\_\_ block the synthesis of bacterial mRNA.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 5

D.) inhibit protein synthesis

Question 6

Antibiotics that \_\_\_\_\_\_\_\_ are most important during incubation.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 6

A.) inhibit cell wall synthesis

Question 7

Antibiotics that \_\_\_\_\_\_\_\_ mimic substrate, para-aminobenzoic acid (PABA) required for folic acid synthesis.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 7

C.) target metabolic pathways

Question 8

Antibiotics that \_\_\_\_\_\_\_\_ cause the leakage of proteins and nucleic acids from the cell.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 8

E.) alter the plasma membrane

Question 9

Antibiotics that \_\_\_\_\_\_\_\_ ultimately results in the inhibition of translation.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 9

B.) inhibit nucleic acid synthesis

Question 10

Antibiotics that \_\_\_\_\_\_\_\_ inhibit replication, and stop transcription.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 10

B.) inhibit nucleic acid synthesis

Question 11

Antibiotics that \_\_\_\_\_\_\_\_ act at the level of transcription and translation.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 11

D.) inhibit protein synthesis

Question 12

Antibiotics that \_\_\_\_\_\_\_\_ block tRNA attachment and mRNA reading.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 12

D.) inhibit protein synthesis

Question 13

Antibiotics that \_\_\_\_\_\_\_\_ result in a weakened cell wall, lysis, and death of the cell (bactericidal).
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 13

A.) inhibit cell wall synthesis

Question 14

Antibiotics that \_\_\_\_\_\_\_\_ block nucleotide synthesis (DNA and RNA).
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 14

B.) inhibit nucleic acid synthesis

Question 15

Antibiotics that \_\_\_\_\_\_\_\_ act on phospholipids in the cytoplasmic membrane.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 15

E.) alter the plasma membrane

Question 16

Antibiotics that \_\_\_\_\_\_\_\_ prevent the synthesis, elongation, or linkage of peptidoglycan molecules.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 16

A.) inhibit cell wall synthesis

Question 16

Antibiotics that \_\_\_\_\_\_\_\_ inhibit the synthesis of folic acid which is a precursor to nucleic acids and amino acids.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 16

C.) target metabolic pathways

Question 17

Antibiotics that \_\_\_\_\_\_\_\_ disrupt cell membrane function.
A.) inhibit cell wall synthesis
B.) inhibit nucleic acid synthesis
C.) target metabolic pathways
D.) inhibit protein synthesis
E.) alter the plasma membrane

Answer 17

E.) alter the plasma membrane