Lecture 11- Lecture 10- Cardiac Phys III Flashcards

1
Q

What factors have a high relative risk of CHD

A

Hypertensive systolic BP > 150 (vs120)

High choleterol (>268 mg/dl)

Smoking >20/day

sedentary lifestyle

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2
Q

How does exercise reduce the risk of CHD?

A
  • promotes general
    metabolic wellness
  • improves mental health
  • builds and preserves
    musculoskeletal function
  • increases lifespan
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3
Q

What counts as physical activity?

A
  • UK gov measure physical activity by
    age, gender and ethnicity
  • Moderate activity – activity
    that leads to increase in
    breathing rate.
  • Vigorous activity – activity
    leading to being “out of breath
    or sweating”.
    What counts as physical activity?
    1 min vigorous activity = 2 min moderate
    activity.
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4
Q

What different things does exercise improve regarding cardiac health?

A

-CV risk factors and incidences decrease
-vasclar responses imporve
-physiological cardiac hypertrophy
-metabolic adaptations such as increase in fatty acid oxidation, increase in ATP production
-improved systemic responses
-myocardial oxidative stress: ROS production falls and antioxidant capacity increases

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5
Q

Why is exercise a stressor?

A

Acute exercise activates the
sympathetic nervous system and is
therefore a stressor (healthy stress!!)

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6
Q

What happens when acute exercise triggers the SNS?

A
  1. Acute exercise –> SNS (adrenaline)
  2. Metabolic and CV homeostasis is initiated
  3. Heat/fluid regulation is triggered
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7
Q

What is chronic training? What are the effects of this?

A

Chronic exercise causes adaptation in
key peripheral organs involved in the
regulation of energy homeostasis and
associated whole-body metabolic effects
and systemic health effects.

-Exercise training:
* improves ˙O2max, 𝑉
* decreases resting heart rate
* decreases blood pressure,
* increases total muscle mass.

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8
Q

What is the difference in cardiac hypertrophy when caused by physiologic and pathologic reasons?

A

pathologic are unhealthy and alot more pronounced distinctions

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9
Q

What is sarcopenia?

A

Sarcopenia is a progressive and generalized skeletal muscle disorder characterized by the loss of muscle mass, strength, and function associated with aging

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10
Q

How does eccentric and concentric exercise affect the heart muscle? What is calculated as eccentric and concentric exercise

A

Eccentric vs concentric
Eccentric  increase in cardiac
mass where RWT is maintained
resulting in coordinated increase in
chamber size and wall thickness.
Concentric  increase in cardiac
mass accompanied by a
disproportionate increase in wall
thickness relative to chamber size.
Concentric cardiac growth is
correlated with worse clinical
outcomes when coupled to cardiac
disease

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11
Q

How does exercise affect the heart rate regulation?

A
  • Cardiac muscles possesses intrinsic rhythmicity.
    (Without external stimuli: HR = 70-100 bpm)
  • Nerves that supply the myocardium and chemicals within the blood can rapidly alter HR –
    Extrinsic factors.
  • Extrinsic control can result in accelerated HR (even due to ‘anticipation’ of exercise) and the
    exercise itself: up to 220 bpm
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12
Q

What happens to blood flow when you exercise?

A

During exercise: Increased energy expenditure requires rapid readjustments in
blood flow (sympathetic response).

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13
Q

Why do the cardiovascular and pulmonary systems work together during exercise?

A
  • Integration of the cardiovascular and pulmonary systems allow for increased demand
    for O2 and blood flow during exercise
  • pulmonary system ensures the uptake of more oxygen
  • the cardiovascular system ensures its transportation
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14
Q

What are the cardiovascular changes that occur after training?

A
  • Cardiovascular changes after training
  • Blood flow redistribution
  • Cardiac output – Stroke Volume (EDV & ESV) & HR
  • VO2
    /HR
  • Blood Pressure – altered BPS, BPD, MAP
  • ejection fraction
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15
Q

What is the difference between heart rate and stroke volume during exercise?

A

SV hits a platau faster and at a lower speed

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16
Q

What does Q max represent and what happens to is during exercise?

A

Q max =SV×HR
Maximal Cardiac Output (Qmax): The combined effects of increased heart rate and stroke volume lead to a significant rise in maximal cardiac output (Qmax) during exercise. This allows for a greater delivery of oxygenated blood to the working muscles and other tissues to meet the increased metabolic demands

17
Q

What is the difference in cardiac output and stroke volume between trained, untrained and elite athletes?

A

REST
Untrained: 5 L.min-1 = 70 b.min-1 x 71 ml
Trained: 5 L.min-1 = 50 b.min-1 x 100 ml
Larger SV in trained individual means lower resting HR

MAXIMAL EXERCISE
Untrained: 22 L.min-1 = 195 b.min-1 x 113 ml
Trained: 35 L.min-1 = 195 b.min-1 x 179 ml
Larger SV in trained individual means greater maximum
cardiac output

18
Q

What is the distribution of blood during exercise?

A

84% is distributed to the muscles

19
Q

What 2 mechanisms control redistribution? What regulates these systems?

A

Maximal Cardiac Output (Qmax): The combined effects of increased heart rate and stroke volume lead to a significant rise in maximal cardiac output (Qmax) during exercise. This allows for a greater delivery of oxygenated blood to the working muscles and other tissues to meet the increased metabolic demands

20
Q

During exercise what happens to the arteriovenous oxygen difference and why?

A

The a-vO2
diff ↑ as venous oxygen
concentration ↓ during exercise due
to the body extracting oxygen from
the blood.

21
Q

During exercise what happens to plasma volume and why?

A

Plasma volume ↓ during exercise due
to water being drawn from the blood
plasma and out of the body as sweat
→Haemoconcentration
↓ Plasma volume → ↑concentration
of red blood cells per unit of blood →
↑ oxygen-carrying capacity

22
Q

What happens to blood pH during exercise and why?

A

Blood pH ↓ due to ↑ blood lactate
accumulation → shift in O2
haemoglobin dissociation curve

23
Q

What happens to blood volume, plasma volume and red blood cell volume post-training?

A

post training: plasma volume and number or red blood cells increases.
total blood volume increases
-Hematocrit% falls