Lecture 11 Ethics

Question 1

What are some ethical concerns regarding clinical trials and how is it mediated?

Answer 1

Slide 2

Question 2

Why is RCT the gold standard in mediating ethics concern in clinical trials?

Answer 2

Slide 3, 4

Question 3

What are some of the ethical principles in research?

Answer 3

Slide 5

Question 4

Was Case Study 1 ethical? Discuss

Answer 4

Slide 6, 7, 8, 9

Question 5

What was the issue with the chloroquine and hydroxychloroquine trials?

Answer 5

Slide 12
- Lack of randomization: No justice, causes bias as not all patients were treated equitably
- Lack of blinding: Open label, may have placebo effect, are the results really based on the drug?
- Small sample size: Could lead to bias in results, better than actual, can the results be trusted?

Question 6

What was done well in the randomized trial of Remdesivir?

Answer 6

Slide 13, 14

Question 7

What was the issue with the Remdesivir trial done by WHO Dec 2020?

Answer 7

Slide 15

Question 8

What was the issue with the Remdesivir trial done in Iran?

Answer 8

Slide 16

Question 9

What was the issue with the Chinese medicine as COVID-19 treatment?

Answer 9

Slide 18, 19, 20