Lecture 11

Question 1

Main goal of Pharmacogenomics

Answer 1

1) search for new drugs + targets

2) Influence of genetic variations on drug response in patients

Question 2

Drug Response

Answer 2

• 30% of B-blockers are ineffective

- antidepressants are 50% ineffective

Question 3

Idiosyncratic

Answer 3

-genetic variation which codes for a protein that is not drug target or part of pharmokinetic pathway but can cause side effects

Question 4

Eg of Idiosyncratic

Answer 4

Favism: antimalarial drugs can cause hemolysis

Question 5

Difficulties in Pharmcogenomic Researches

Answer 5

1) Phenocopy
2) Gene gene interaction
3) ethic differences