Lecture 11 (2/15) Flashcards
NMDA receptor is a ______ detector.
NMDA receptor is a coincidence detector.
Collinrige LTP discovery
NMDA receptor antagonist APV inhibits LTP
Lynch LTP discovery
Chelating postsynaptic Ca2+ inhibits LTP
2 common LTP protocols
1) ________ stimulation
2) _________ stimulation paired with _________
2 common LTP protocols
1) tetanus (high frequency) stimulation
2) low frequency stimulation paired with post synaptic membrane depolarization
Opening of NMDArs requires
1) Presynaptic ______ release
2) Postsynaptic __________
1) Presynaptic glutamate release
2) Postsynaptic depolarization
For CaMKII, when the stimulus is weak, there is activation _________.
When the stimulus is strong, there is activation ___________.
For CaMKII, when the stimulus is weak, there is activation without autophosphorylation.
When the stimulus is strong, there is activation by autophosphorylation.
What is the significance of T286?
T286 phosphorylation impairs the inhibitory effect of the regulatory subunit, so that the activity of the phosphorylated subunits persists even after Ca2+/calmodulin dissociates.
The processing creates a “memory” in the CaMKII molecule, until phosphatases erase this persistent kinase activity by dephosphorylation T286.
Mechanisms through which CaMKII activation leads to LTP
1) Phosphorylation of AMPArs increases their _________
2) Promote trafficking of _________ into synapse
3) Phosphorylate __________ at the postsynaptic density (PSD) to create docking sites for AMPArs in postsynaptic membrane
4) Activating _________ and expressing ________ for long-lasting functional and structural changes in synaptic efficacy
Mechanisms through which CaMKII activation leads to LTP
1) Phosphorylation of AMPArs increases their ionic conductance
2) Promote trafficking of intracellular AMPArs into synapse
3) Phosphorylate scaffold proteins at the postsynaptic density (PSD) to create docking sites for AMPArs in postsynaptic membrane
4) Activating transcription factors and expressing new genes for long-lasting functional and structural changes in synaptic efficacy
The promotion of actin polymerization in the head and neck of dendritic spines causes:
1) Creates available slots for ___________
2) Create _________ for supporting the transport and ultimate fusion of AMPA receptor-containing vesicles in the spine head
The promotion of actin polymerization in the head and neck of dendritic spines causes:
1) Creates available slots for synaptic AMAPrs
2) Create additional tracks for supporting the transport and ultimate fusion of AMPA receptor-containing vesicles in the spine head
NMDA receptor is a _______ detector
coincidence
Induction of LTP in CA1 neurons shows cooperativity, which is
The nearly simultaneous activation of a large number of afferent axons to induce LTP
Induction of LTP in CA1 neurons shows associativity, which is
A synaptic modification in one afferent input to a neuron that is conditional upon coactivity in a separate input to the same neuron.
Induction of LTP in CA1 neurons shows synapse specificity, which is
3 characteristics present in induction of LTP in CA1 neurons
1) Cooperativity
2) Associativity
3) Synapse specificity
The low-frequency tetanus stiumulus induces ________ at Schaffer collateral synapses.
The low-frequency tetanus stiumulus induces long-term depression at Schaffer collateral synapses.