Lecture 10_Fall

Question 1

Name 2 non selective Alpha receptor antagonists.

Answer 1

Phentolamine and Phenoxybenzamine

Question 2

T or F A2 receptor blockade leads to tachycardia

Answer 2

True. It eliminates negative feedback which leads to more NE release.

Question 3

___ and ____ are almost exclusively for the mgmt of pheochromocytomas

Answer 3

Phentolamine and Phenoxybenzamine

Question 4

____ reversibly binds to alpha receptors, causes vasodilation, is a treatment for NE extravasation and is a reversal of LA injection

Answer 4

Phentolamine

Question 5

___ irreversibly binds to alpha receptors and an overdose of this drug is treated with NE

Answer 5

Phenoxybenzamine

Question 6

___ is a non selective beta antagonist that has been associated with rebound HTN, tachycardia and angina when patients stop taking it due to the up-regulation of beta receptors

Answer 6

Propranolol (Inderal)

Question 7

What type of beta blocker should be used in pts w/ reactive airway disease?

Answer 7

B1 selective antagonist

Question 8

____ is an ultra short acting B1 selective antagonist.

Answer 8

Esmolol (BreviBloc)

Question 9

____ is the common drug of choice for intraop HTN because decreases PVR and renin, and causes some decrease in HR.

Answer 9

Labetalol

Question 10

The main indication for use of which beta blocker is treatment of a thyroid storm (thyrotoxicosis) or pheochromocytomas?

Answer 10

Propranolol (Inderal)

Question 11

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Atenolol

Answer 11

B1 selective antagonist

Question 12

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Labetalol

Answer 12

Mixed antagonist (A1 B1 and B2)

Question 13

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Carvedilol.

Answer 13

B1 selective antagonist

Question 14

This non-selective beta blocker is no longer commonly used because of its following side effects: bronchospasm, CHF, bradycardia and AV heart block.

Answer 14

Propranolol (Inderal)

Question 15

Is the following a mixed, non-selective Beta, or a B1 selective adrenergic antagonist?

Metoprolol

Answer 15

B1 selective antagonist

Question 16

This adrenergic antagonist’s short duration of action is due to its rapid redistribution (2 min) and ester hydrolysis (9 min).

Answer 16

Esmolol (BreviBloc)

Question 17

T or F. Labetalol causes reflex tachycardia.

Answer 17

False. It is a mixed antagonist with alpha and beta receptor antagonism.

Question 18

___ is a good choice for preventing tachycardia and hypertension during intubation and emergence.

Answer 18

Esmolol

Question 19

What are 3 side effects associated with alpha-1 receptor blockade?

Answer 19

Side effects: hypotension, orthostatic hypotension, tachycardia

Question 20

Phenylephrine will have what effect on a patient who has taken Phenoxybenzamine?

Answer 20

No effect. Phenylephrine response is completely blocked

Question 21

NE will have what effect on a patient who has taken Phenoxybenzamine?

Answer 21

Norepinephrine response: tachycardia due to B1 activation

Question 22

Epi will have what effect on a patient who has taken Phenoxybenzamine?

Answer 22

Epinephrine response: tachycardia and severe hypotension due to B2-mediated vasodilation

Question 23

How does an alpha-2 receptor blockade work and what does it cause?

Answer 23

A2-receptor blockade -> eliminates negative feedback -> more NE release -> tachycardia

Question 24

When treating a pheochromocytoma, which should you do first and which should you do second…alpha block vs beta block.

Answer 24

A-blockade before B-blockade