Lecture 10: Regulation of Carbohydrate Metabolism Flashcards
1
Q
which enzymes are regulated to regulate glycolysis
A
- PFK-1
- pyruvate kinase
2
Q
what is the starting point of gluconeogenesis
A
oxaloacetate
3
Q
which factors regulate PFK-1 activity
A
- ATP inhibits
- AMP stimulates
- H+ ions inhibits
- F-6-P stimulates
- F-2,6-BP stimulates
- citrate inhibits
4
Q
which hormones regulate gluconeogenesis
A
stimulated in short term by: - glucagon - adrenaline stimulated in long term by: - glucagon - glucocorticoids - thyroid hormones inhibited acutely by: - insulin
5
Q
what does F-2,6-BP do
A
- made from F-6-P by PFK-2
- most potent allosteric activator of PFK-1
